Diagnostic yield of tuberculosis using sputum induction in HIV-positive patients before antiretroviral therapy

被引：18

作者：

Lawn, S. D. ^{[1
,2
]}

Kerkhoff, A. D. ^{[1
,3
]}

Pahlana, P. ^{[1
]}

Vogt, M. ^{[1
]}

Wood, R. ^{[1
]}

机构：

[1] Univ Cape Town, Desmond Tutu HIV Ctr, Inst Infect Dis & Mol Med, Fac Hlth Sci, ZA-7925 Cape Town, South Africa

[2] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Clin Res, London WC1, England

[3] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2012年 / 16卷 / 10期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

HIV; tuberculosis; screening; diagnosis; Africa; sputum induction; antiretroviral; SUB-SAHARAN AFRICA; PULMONARY TUBERCULOSIS; OUTCOMES; ASSAY;

D O I：

10.5588/ijtld.12.0174

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Adults (n = 602) enrolling in a South African antiretroviral treatment clinic underwent culture-based screening for tuberculosis (TB), regardless of symptoms. For those unable to spontaneously expectorate a 'spot' sample (n = 124), sputum induction with nebulised hypertonic saline was used to obtain a first sample and also to rapidly obtain a second sample from all patients. Collection of both samples typically took 10-15 min. The prevalence of culture-positive TB was 15.6% (95%CI 12.8-18.8). Spontaneously expectorated spot samples yielded 79.8% of all culture-positive TB diagnoses. The incremental yield from those needing an induced first sample was 5.3% and the yield from induced second samples was 14.9%.

引用

页码：1354 / 1357

页数：4

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