Closed-loop insulin delivery: update on the state of the field and emerging technologies

被引：24
作者：
Ware, Julia [1 ,2 ]
Hovorka, Roman [1 ,2 ]
机构：
[1] Univ Cambridge, Wellcome Trust MRC Inst Metab Sci, Cambridge, England
[2] Univ Cambridge, Dept Pediat, Cambridge, England
来源：
EXPERT REVIEW OF MEDICAL DEVICES | 2022年 / 19卷 / 11期
基金：
欧盟地平线“2020”;
关键词：
Artificial pancreas; automated insulin delivery; hybrid closed-loop; continuous glucose monitoring; insulin pump; type; 1; diabetes; AUGMENTED PUMP THERAPY; ARTIFICIAL PANCREAS; GLYCEMIC CONTROL; RANDOMIZED-TRIAL; GLUCOSE CONTROL; YOUNG-ADULTS; BIONIC PANCREAS; ADVERSE EVENTS; TYPE-1; ADOLESCENTS;
D O I：
10.1080/17434440.2022.2142556
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Introduction Over the last five years, closed-loop insulin delivery systems have transitioned from research-only to real-life use. A number of systems have been commercialized and are increasingly used in clinical practice. Given the rapidity of new developments in the field, understanding the capabilities and key similarities and differences of current systems can be challenging. This review aims to provide an update on the state of the field of closed-loop insulin delivery systems, including emerging technologies. Areas covered We summarize key clinical safety and efficacy evidence of commercial and emerging insulin-only hybrid closed-loop systems for type 1 diabetes. A literature search was conducted and clinical trials using closed-loop systems during free-living conditions were identified to report on safety and efficacy data. We comment on emerging technologies and adjuncts for closed-loop systems, as well as non-technological priorities in closed-loop insulin delivery. Expert opinion Commercial hybrid closed-loop insulin delivery systems are efficacious, consistently improving glycemic control when compared to standard therapy. Challenges remain in widespread adoption due to clinical inertia and the lack of resources to embrace technological developments by health care professionals.
引用
收藏
页码：859 / 875
页数：17
相关论文
共 148 条
[61]   Sensor-augmented insulin pump therapy: Results of the first randomized treat-to-target study [J].
Hirsch, Irl B. ;
Abelseth, Jill ;
Bode, Bruce W. ;
Fischer, Jerome S. ;
Kaufman, Francine R. ;
Mastrototaro, John ;
Parkin, Christopher G. ;
Wolpert, Howard A. ;
Buckingham, Bruce A. .
DIABETES TECHNOLOGY & THERAPEUTICS, 2008, 10 (05) :377-383
[62]   Lived experience of CamAPS FX closed loop system in youth with type 1 diabetes and their parents [J].
Hood, Korey K. ;
Garcia-Willingham, Natasha ;
Hanes, Sarah ;
Tanenbaum, Molly L. ;
Ware, Julia ;
Boughton, Charlotte K. ;
Allen, Janet M. ;
Wilinska, Malgorzata E. ;
Tauschmann, Martin ;
Denvir, Louise ;
Thankamony, Ajay ;
Campbell, Fiona ;
Wadwa, R. Paul ;
Buckingham, Bruce A. ;
Davis, Nikki ;
DiMeglio, Linda A. ;
Mauras, Nelly ;
Besser, Rachel Ej ;
Ghatak, Atrayee ;
Weinzimer, Stuart A. ;
Fox, D. Steven ;
Kanapka, Lauren ;
Kollman, Craig ;
Sibayan, Judy ;
Beck, Roy W. ;
Hovorka, Roman .
DIABETES OBESITY & METABOLISM, 2022, 24 (12) :2309-2318
[63]   Lived Experience of Advanced Hybrid Closed-Loop Versus Hybrid Closed-Loop: Patient-Reported Outcomes and Perspectives [J].
Hood, Korey K. ;
Laffel, Lori M. ;
Danne, Thomas ;
Nimri, Revital ;
Weinzimer, Stuart A. ;
Sibayan, Judy ;
Bailey, Ryan J. ;
Schatz, Desmond ;
Bratina, Natasa ;
Bello, Rachel ;
Punel, Alina ;
Calhoun, Peter ;
Beck, Roy W. ;
Bergenstal, Richard M. ;
Phillip, Moshe .
DIABETES TECHNOLOGY & THERAPEUTICS, 2021, 23 (12) :857-861
[64]   Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: crossover randomised controlled studies [J].
Hovorka, Roman ;
Kumareswaran, Kavita ;
Harris, Julie ;
Allen, Janet M. ;
Elleri, Daniela ;
Xing, Dongyuan ;
Kollman, Craig ;
Nodale, Marianna ;
Murphy, Helen R. ;
Dunger, David B. ;
Amiel, Stephanie A. ;
Heller, Simon R. ;
Wilinska, Malgorzata E. ;
Evans, Mark L. .
BMJ-BRITISH MEDICAL JOURNAL, 2011, 342
[65]   Overnight Closed- Loop Insulin Delivery in Young People With Type 1 Diabetes: A Free- Living, Randomized Clinical Trial [J].
Hovorka, Roman ;
Elleri, Daniela ;
Thabit, Hood ;
Allen, Janet M. ;
Leelarathna, Lalantha ;
El-Khairi, Ranna ;
Kumareswaran, Kavita ;
Caldwell, Karen ;
Calhoun, Peter ;
Kollman, Craig ;
Murphy, Helen R. ;
Acerini, Carlo L. ;
Wilinska, Malgorzata E. ;
Nodale, Marianna ;
Dunger, David B. .
DIABETES CARE, 2014, 37 (05) :1204-1211
[66]   Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial [J].
Hovorka, Roman ;
Allen, Janet M. ;
Elleri, Daniela ;
Chassin, Ludovic J. ;
Harris, Julie ;
Xing, Dongyuan ;
Kollman, Craig ;
Hovorka, Tomas ;
Larsen, Anne Mette F. ;
Nodale, Marianna ;
De Palma, Alessandro ;
Wilinska, Malgorzata E. ;
Acerini, Carlo L. ;
Dunger, David B. .
LANCET, 2010, 375 (9716) :743-751
[67]   Expectations and Attitudes of Individuals With Type 1 Diabetes After Using a Hybrid Closed Loop System [J].
Iturralde, Esti ;
Tanenbaum, Molly L. ;
Hanes, Sarah J. ;
Suttiratana, Sakinah C. ;
Ambrosino, Jodie M. ;
Ly, Trang T. ;
Maahs, David M. ;
Naranjo, Diana ;
Walders-Abramson, Natalie ;
Weinzimer, Stuart A. ;
Buckingham, Bruce A. ;
Hood, Korey K. .
DIABETES EDUCATOR, 2017, 43 (02) :223-232
[68]   The Cost-Effectiveness of an Advanced Hybrid Closed-Loop System in People with Type 1 Diabetes: a Health Economic Analysis in Sweden [J].
Jendle, Johan ;
Buompensiere, M. I. ;
Holm, A. L. ;
de Portu, S. ;
Malkin, S. J. P. ;
Cohen, O. .
DIABETES THERAPY, 2021, 12 (11) :2977-2991
[69]   Do-It-Yourself Artificial Pancreas Systems: A Review of the Emerging Evidence and Insights for Healthcare Professionals [J].
Jennings, Peter ;
Hussain, Sufyan .
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, 2020, 14 (05) :868-877
[70]   Patient Time Costs Associated with Sensor-Augmented Insulin Pump Therapy for Type 1 Diabetes: Results from the STAR 3 Randomized Trial [J].
Kamble, Shital ;
Weinfurt, Kevin P. ;
Schulman, Kevin A. ;
Reed, Shelby D. .
MEDICAL DECISION MAKING, 2013, 33 (02) :215-224
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