Laryngeal cleft is a rare congenital anomaly that is recently being diagnosed with increased frequency. The objective of this report is to present a comprehensive description of endoscopic laser repair of a laryngeal cleft, using both the carbon dioxide (CO2) laser via a micromanipulator (Carl Zeiss Microimaging Inc., Thornwood, NY) and the flexible CO2 laser fiber (OmniGuide, Inc.; Cambridge, MA), from both an anesthesia and surgical perspective. Laryngoscope, 2013