Genistein down-modulates pro-inflammatory cytokines and reverses clinical signs of experimental autoimmune encephalomyelitis

被引：58

作者：

De Paula, Marcio L.

Rodrigues, David H. ^{[2
]}

Teixeira, Henrique C.

Barsante, Michele M.

Souza, Maria A.

Ferreira, Ana P. ^{[1
]}

机构：

[1] Fed Univ Juiz Fora, Inst Biol Sci, Immunol Lab, Dept Parasitol Microbiol & Immunol, BR-36036900 Juiz De Fora, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2008年 / 8卷 / 09期

关键词：

multiple sclerosis; experimental autoimmune encephalomyelitis; genistein; cytokines; intravital microscopy;

D O I：

10.1016/j.intimp.2008.05.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is the most common non-traumatic, disabling neurological human inflammatory demyelinating disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) models MS and is characterized as a CD4+ T-helper type 1 (Th1) cell-mediated autoimmune disease. It is characterized by an influx of activated leukocytes into the CNS. Genistein, occurring abundantly in soy products, has apoptotic, antioxidant, and anti-inflammatory properties. In the present report, we investigated the use of genistein for the treatment of the murine model of MS. After induction of EAE with myelin oligodendrocyte glycoprotein 35-55 peptide (MOG(35-55)), we observed that genistein treatment ameliorated significantly the clinical symptoms, modulating pro- and anti-inflammatory cytokines. Moreover, we analyzed the Leukocyte roiling and adherence in the CNS by performing intravital microscopy. Genistein treatment resulted in decreased rotting and adhering of leukocytes as compared to the untreated group. Our data suggest that genistein might be a potential therapy for MS. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：1291 / 1297

页数：7

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