Chemical constituents from the aerial parts of Codonopsis nervosa

AIM: To study the chemical constituents of the aerial parts of Codonopsis nervosa (Chipp.) Nannf. (Campanulaceae), a commonly used Tibetan herb. METHODS: The constituents were isolated by D-101 porous polymer resin, silica gel, ODS and Sephadex LH-20 column chromatography, and their structures were elucidated on the basis of spectroscopic analysis. RESULTS: 15 compounds were isolated and identified as chrysoeriol (1), tricin (2), apigenin (3), succinic acid (4), beta-sitosterol-3-O-beta-D-glucopyranoside (5), luteolin (6), lutcolin-7-O-beta-D-glucopyranoside (7), ethylsyringin (8), apigenin-7-O-beta-D-glucopyranoside (9), luteolin-7-O-beta-D-glucopyranosyl-(1 -> 6)-[6'''-O-caffeoyl]-beta-D-glucopyranoside (10), luteolin-7-O-beta-D-gentiobioside (11), syringin (12), 3-O-caffeoylquinic acid (13), 5-O-caffeoylquinic acid (14), and 4-O-(beta-D-glucopyranosyl)-benzoic acid (15), respectively. CONCLUSION: Compounds 1-5, 8, 9, 12, 14, 15 were reported from C. nervosa for the first time.