Preparation of quinolines by reduction of ortho-nitroarenes with zinc in near-critical water

被引：30

作者：

Boix, C

de la Fuente, JM

Poliakoff, M

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] Univ Cordoba, Dept Quim Organ, E-14004 Cordoba, Spain

来源：

NEW JOURNAL OF CHEMISTRY | 1999年 / 23卷 / 06期

关键词：

D O I：

10.1039/a902554e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a preparation of quinoline 2 and indole 4 derivatives by reduction of suitably functionalised o-nitroarenes with Zn powder in H2O at 250 degrees C. The process involves the reduction of the nitro group to an amino group followed by in situ cyclisation with a carbonyl or alcohol moiety in an aqueous medium. The amount of hydroquinoline 3 produced depends on the nature of the carbonyl moiety of the nitroarene.

引用

页码：641 / 643

页数：3

共 24 条

[1] Hydrolysis and saponification of methyl benzoates -: A green procedure in high temperature water [J].