Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome

被引：10

作者：

Burt, EC

McGown, G

Thorncroft, M

James, LA

Birch, JM

Varley, JM

机构：

[1] Paterson Inst Canc Res, CRC, Mol Genet Sect, Manchester M20 4BX, Lancs, England

[2] Royal Manchester Childrens Hosp, CRC, Paed & Familial Canc Res Grp, Manchester M27 1HA, Lancs, England

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 80卷 / 1-2期

关键词：

Li-Fraumeni syndrome; PTEN; CDKN2; p16; p19(ARF);

D O I：

10.1038/sj.bjc.6690313

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.

引用

页码：9 / 10

页数：2

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