Effect of high fat diets on the NTPDase, 5′-nucleotidase and acetylcholinesterase activities in the central nervous system

被引:6
|
作者
Kaizer, Rosilene Rodrigues [1 ,2 ]
Spanevello, Roselia Maria [3 ]
Costa, Eduarda [3 ]
Morsch, Vera Maria [3 ]
Chitolina Schetinger, Maria Rosa [3 ]
机构
[1] Inst Fed Educ Ciencia & Tecnol Rio Grande Sul, Campus Sertao,Rodovia ERS 135 Km 25, BR-99170000 Sertao, RS, Brazil
[2] Univ Fed Fronteira Sul, Programa Posgrad Ciencia & Tecnol Ambiental, Campus Erechim,Rodovia ERS 135 Km 72,200, BR-99700970 Erechim, RS, Brazil
[3] Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, Dept Bioquim, Ctr Ciencias Nat & Exatas, Av Roraima, BR-97105900 Santa Maria, RS, Brazil
关键词
Adenine nucleotides; Hydrolysis; Purinergic; Cholinergic; Alzheimer disease; IN-VITRO; ALUMINUM; ECTONUCLEOTIDASES; SYNAPTOSOMES; SECRETION; PROTEIN; GAMMA; ATP;
D O I
10.1016/j.ijdevneu.2017.02.007
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
High fat diets are associated with the promotion of neurological diseases, such as Alzheimer disease (AD). This study aim investigate the high fat diets role to promotion of AD using as biochemistry parameter of status of central nervous system through the NTPDase, 5`-nucleotidase and acetylcholinesterase (AChE) activities in brain of young rats. The intake of high fat diets promotes an inhibition of purinergic and cholinergic functions, mainly in the long-term exposure to saturated and saturated/unsaturated diets. The AChE activity was decreased to supernatant and synaptosomes tissues preparations obtained from cerebral cortex in average of 20%, to both groups exposed to saturated and saturated/unsaturated diets, when compared to the control group. Very similar results were found in hippocampus and cerebellum brain areas. At same time, the adenine nucleotides hydrolysis in synaptosomes of cerebral cortex were decreased to ATP. ADP and AMP after the long-term exposure to high fat diets, as saturated and saturated/unsaturated. The inhibition of ATP hydrolysis was of 26% and 39% to saturated and saturated/unsaturated diets, respectively. ADP hydrolysis was decreased in 20% to saturated diet, and AMP hydrolysis was decreased in 25% and 33% to saturated and saturated/unsaturated diets, respectively, all in comparison to the control. Thus, we can suggest that the effects of high diets on the purinergic and cholinergic nervous system may contribute to accelerate the progressive memory loss, to decline in language and other cognitive disruptions, such as AD patients presents. (C) 2017 ISDN. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:54 / 58
页数:5
相关论文
共 50 条
  • [1] Effect of high glucose levels in human platelet NTPDase and 5′-nucleotidase activities
    Lunkes, Gilberto Inacio
    Lunkes, Daniele Sausen
    Leal, Daniela
    Araujo, Maria do Carmo
    Correa, Maisa
    Becker, Lara
    da Rosa, Cintia Saydelles
    Morsch, Vera Maria
    Chitolina Schetinger, Maria Rosa
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2008, 81 (03) : 351 - 357
  • [2] The effect of aluminium on NTPDase and 5′-nucleotidase activities from rat synaptosomes and platelets
    Rodrigues Kaizer, Rosilene
    Acosta Maldonado, Paula
    Maria Spanevello, Roslia
    Correa, Maisa C.
    Goncalves, Jamile F.
    Vargas Becker, Lara
    Maria Morsch, Vera
    Chitolina Schetinger, Maria Rosa
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2007, 25 (06) : 381 - 386
  • [3] Exposure to Hg2+ and Pb2+ changes NTPDase and ecto-5′-nucleotidase activities in central nervous system of zebrafish (Danio rerio)
    Senger, Mario Roberto
    Rico, Eduardo Pacheco
    Arizi, Marcelo De Bem
    Frazzon, Ana Paula Guedes
    Dias, Renato Dutra
    Bogo, Maurfcio Reis
    Bonan, Carla Denise
    TOXICOLOGY, 2006, 226 (2-3) : 229 - 237
  • [4] NTPDase and 5'-nucleotidase activities in platelets of human pregnants with a normal or high risk for thrombosis
    Leal, Claudio A. M.
    Schetinger, Maria R. C.
    Leal, Daniela B. R.
    Bauchspiess, Karine
    Schrekker, Clarissa M. L.
    Maldonado, Paula A.
    Morsch, Vera M.
    da Silva, Jose E. P.
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2007, 304 (1-2) : 325 - 330
  • [5] NTPDase and 5′-nucleotidase activities in platelets of human pregnants with a normal or high risk for thrombosis
    Claudio A. M. Leal
    Maria R. C. Schetinger
    Daniela B. R. Leal
    Karine Bauchspiess
    Clarissa M. L. Schrekker
    Paula A. Maldonado
    Vera M. Morsch
    José E. P. da Silva
    Molecular and Cellular Biochemistry, 2007, 304 : 325 - 330
  • [6] Inhibition of NTPDase, 5′-nucleotidase, Na+/K+-ATPase and acetylcholinesterase activities by subehronic treatment with Casearia sylvestris
    da Silva, A. C.
    Balz, D.
    de Souza, J. B. D'A.
    Morsch, V. M.
    Correa, M. C.
    Zanetti, G. D.
    Manfron, M. P.
    Schetinger, M. R. C.
    PHYTOMEDICINE, 2006, 13 (07) : 509 - 514
  • [7] Effect of subchronic treatment with mercury chloride on NTPDase, 5′-nucleotidase and acetylcholinesterase from cerebral cortex of rats
    Moretto, MB
    Lermen, CL
    Morsch, VM
    Bohrer, D
    Ineu, RP
    da Silva, AC
    Balz, D
    Schetinger, MRC
    JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2003, 17 (04) : 255 - 260
  • [8] Rat submandibular glands secrete nanovesicles with NTPDase and 5'-nucleotidase activities
    Gonzalez, Debora A.
    Egido, Patricia
    Balcarcel, Noelia B.
    Hattab, Claude
    van Haaster, Martin M. Barbieri
    Pelletier, Julie
    Sevigny, Jean
    Ostuni, Mariano A.
    PURINERGIC SIGNALLING, 2015, 11 (01) : 107 - 116
  • [9] Rat submandibular glands secrete nanovesicles with NTPDase and 5′-nucleotidase activities
    Débora A. González
    Patricia Egido
    Noelia B. Balcarcel
    Claude Hattab
    Martín M. Barbieri van Haaster
    Julie Pelletier
    Jean Sévigny
    Mariano A. Ostuni
    Purinergic Signalling, 2015, 11 : 107 - 116
  • [10] NTPDase and 5′-nucleotidase activities in rats with alloxan-induced diabetes
    Lunkes, GIL
    Lunkes, DS
    Morsch, VM
    Mazzanti, CM
    Morsch, ALB
    Miron, VR
    Schetinger, MRC
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2004, 65 (01) : 1 - 6