Estimating burden of influenza-associated influenza-like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12-2015/16 influenza seasons

被引:15
作者
Gefenaite, Giedre [1 ,2 ]
Pistol, Adriana [3 ]
Popescu, Rodica [3 ]
Popovici, Odette [3 ]
Ciurea, Daniel [4 ]
Dolk, Christiaan [1 ,5 ]
Jit, Mark [6 ]
Gross, Diane [1 ]
机构
[1] WHO Reg Off Europe, Infect Hazards Management, Div Hlth Emergencies & Communicable Dis, Copenhagen, Denmark
[2] Lund Univ, Dept Hlth Sci, Fac Med, Lund, Sweden
[3] Natl Inst Publ Hlth, Natl Ctr Communicable Dis Surveillance & Control, Bucharest, Romania
[4] Ctr Hlth Policies & Serv, Bucharest, Romania
[5] Univ Groningen, Groningen Res Inst Pharm, PharmacoTherapy Epidemiol & Econ, Groningen, Netherlands
[6] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, Fac Epidemiol & Populat Hlth, London, England
关键词
burden; influenza-like illness; severe acute respiratory infection;
D O I
10.1111/irv.12525
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
BackgroundInfluenza is responsible for substantial morbidity and mortality, but there is limited information on reliable disease burden estimates, especially from middle-income countries in the WHO European Region. ObjectivesTo estimate the incidence of medically attended influenza-associated influenza-like illness (ILI) and hospitalizations due to severe acute respiratory infection (SARI) presenting to public healthcare facilities in Romania. Patients/MethodsSentinel influenza surveillance data for ILI and SARI from 2011/12-2015/16, including virological data, were used to estimate influenza-associated ILI and SARI incidence/100000 and their 95% confidence intervals (95% CI). ResultsThe overall annual incidence of ILI and influenza-associated ILI per 100000 persons in Romania varied between 68 (95% CI: 61-76) and 318 (95% CI: 298-338) and between 23 (95% CI: 19-29) and 189 (95% CI: 149-240), respectively. The highest ILI and influenza incidence was among children aged 0-4years. We estimated that SARI incidence per 100000 persons was 6 (95% CI: 5-7) to 9 (95% CI: 8-10), of which 2 (95% CI: 1-2) to 3 (95% CI: 2-4) were due to influenza. Up to 0.3% of the Romanian population were annually reported with ILI, and 0.01% was hospitalized with SARI, of which as much as one-third could be explained by influenza. ConclusionsThis evaluation was the first study estimating influenza burden in Romania. We found that during each influenza season, a substantial number of persons in Romania suffer from influenza-related ILI or are hospitalized due to influenza-associated SARI.
引用
收藏
页码:183 / 192
页数:10
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