Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy

被引：79

作者：

Dorniani, Dena ^{[1
,2
]}

Saifullah, Bullo ^{[2
]}

Barahuie, Farahnaz ^{[2
,3
]}

Arulselvan, Palanisamy ^{[4
]}

Bin Hussein, Mohd Zobir ^{[2
]}

Fakurazi, Sharida ^{[4
,5
]}

Twyman, Lance J. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Dainton Bldg,Brook Hill, Sheffield S3 7HF, S Yorkshire, England

[2] Univ Putra Malaysia, Inst Adv Technol, Mat Synth & Characterizat Lab, Serdang 43400, Malaysia

[3] Zabol Univ Med Sci, Dept Chem, Zabol, Iran

[4] Univ Putra Malaysia, Inst Biosci, Lab Vaccines & Immunotherapeut, Serdang 43400, Malaysia

[5] Univ Putra Malaysia, Dept Human Anat, Fac Med & Hlth Sci, Serdang 43400, Malaysia

来源：

NANOSCALE RESEARCH LETTERS | 2016年 / 11卷

关键词：

Drug delivery systems; Graphene oxide; Gallic acid; Controlled-release; Cytotoxicity; CONTROLLED-RELEASE FORMULATION; DRUG-DELIVERY; GREEN; NANOPARTICLES; NANOSHEETS;

D O I：

10.1186/s11671-016-1712-2

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (GOGA) was characterized using XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy. The release study shows that the release of GA from the designed anticancer nanocomposite (GOGA) occurs in a sustained manner in phosphate- buffered saline (PBS) solution at pH 7.4. In in vitro biological studies, normal fibroblast (3T3) and liver cancer cells (HepG2) were treated with different concentrations of GO, GOGA, and GA for 72 h. The GOGA nanocomposite showed the inhibitory effect to cancer cell growth without affecting normal cell growth. The results of this research are highly encouraging to go further for in vivo studies.

引用

页数：9

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