Overexpression of Bmi-1 Induces the Malignant Transformation of Gastric Epithelial Cells In Vitro

被引：19

作者：

Chen, Yinting ^{[1
]}

Lian, Guoda ^{[1
]}

Zhang, Qiubo ^{[1
]}

Zeng, Linjuan ^{[2
]}

Qian, Chenchen ^{[1
]}

Chen, Shaojie ^{[1
]}

Huang, Kaihong ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Oncol, Zhuhai, Peoples R China

来源：

ONCOLOGY RESEARCH | 2013年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1); Malignant transformation; Gastric epithelial cells; Gastric cancer; POLYCOMB GROUP; CANCER; EXPRESSION; CARCINOMA; INVASIVENESS; ONCOPROTEIN; PROGRESSION; PROGNOSIS; MEL-18; MICE;

D O I：

10.3727/096504013X13786659070316

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncogene Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) has attracted much attention for its involvement in the initiation of a variety of tumors. Our previous study showed that Bmi-1 was highly expressed in gastric cancer and correlated with patient prognosis. However, whether aberrant Bmi-1 expression was critical for the transformation of gastric epithelial cells remains unknown. In this study, we stably expressed Bmi-1 in a human gastric epithelial immortalized cell line, GES-1. The overexpression of Bmi-1 promoted cell growth and proliferation, inhibited apoptosis, enhanced clone formation capability, possessed the characteristics of anchorage-independent growth, and increased migration and invasion abilities. Therefore, our findings demonstrated that ectopic expression of Bmi-1 played an important role in the malignant transformation of gastric epithelial cells.

引用

页码：33 / 41

页数：9

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