Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection

被引：32

作者：

Gao, Xiang ^{[1
]}

Zhang, Shengyuan ^{[1
]}

Gou, Jizhou ^{[2
]}

Wen, Yanling ^{[1
]}

Fan, Lujie ^{[3
]}

Zhou, Jian ^{[1
]}

Zhou, Guangde ^{[2
]}

Xu, Gang ^{[1
]}

Zhang, Zheng ^{[1
,4
,5
]}

机构：

[1] Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Shenzhen Peoples Hosp 3, Inst Hepatol,Affiliated Hosp 2,Sch Med, Shenzhen 518112, Guangdong, Peoples R China

[2] Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Dept Pathol,Sch Med, Shenzhen, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Guangzhou Lab, Guangzhou, Guangdong, Peoples R China

[4] Guangdong Key Lab Antiinfect Drug Qual Evaluat, Shenzhen, Guangdong, Peoples R China

[5] Chinese Acad Med Sci, Shenzhen Res Ctr Communicable Dis Diag, Treatment, Shenzhen 518112, Guangdong, Peoples R China

来源：

JOURNAL OF INFECTION | 2022年 / 85卷 / 04期

基金：

中国国家自然科学基金;

关键词：

SARS-CoV-2; Spike; ACE2; Ang II; ANGIOTENSIN-CONVERTING ENZYME; CARDIOVASCULAR-DISEASE; RECEPTOR; PROTEIN;

D O I：

10.1016/j.jinf.2022.06.030

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious threat to human health, with patients reportedly suffering from thrombus, vascular injury and coagulation in addition to acute and diffuse lung injury and respiratory diseases. Angiotensin converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 entry, is also an important regulator of renin-angiotensin system (RAS) homeostasis, which plays an unsettled role in the pathogenesis of COVID-19. Here, we demonstrated that SARSCoV-2 Spike protein activated intracellular signals to degrade ACE2 mRNA. The decrease of ACE2 and higher level of angiotensin (Ang) II were verified in COVID-19 patients. High dose of Ang II induced pulmonary artery endothelial cell death in vitro, which was also observed in the lung of COVID-19 patients. Our finding indicates that the downregulation of ACE2 potentially links COVID-19 to the imbalance of RAS. (C) 2022 Published by Elsevier Ltd on behalf of The British Infection Association.

引用

页码：418 / 427

页数：10

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