Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

被引：122

作者：

Montoliu, Ivan ^{[1
]}

Scherer, Max ^{[2
]}

Beguelin, Fiona ^{[2
]}

DaSilva, Laeticia ^{[2
]}

Mari, Daniela ^{[3
,4
]}

Salvioli, Stefano ^{[5
,6
]}

Martin, Franois-Pierre J. ^{[2
]}

Capri, Miriam ^{[5
,6
]}

Bucci, Laura ^{[5
,6
]}

Ostan, Rita ^{[5
,6
]}

Garagnani, Paolo ^{[5
,6
]}

Monti, Daniela ^{[7
]}

Biagi, Elena ^{[8
]}

Brigidi, Patrizia ^{[8
]}

Kussmann, Martin ^{[2
,9
,10
]}

Rezzi, Serge ^{[2
]}

Franceschi, Claudio ^{[5
,6
]}

Collino, Sebastiano ^{[2
]}

机构：

[1] Nestec Ltd, Nestle Res Ctr, CH-1000 Lausanne, Switzerland

[2] Nestle Inst Hlth Sci SA, Mol Biomarkers Core, CH-1015 Lausanne, Switzerland

[3] Univ Milan, Dept Med Sci, Milan, Italy

[4] Maggiore Policlin Hosp, IRCCS Ca Grande Fdn, Geriatr Unit, Milan, Italy

[5] Univ Bologna, Dept Expt Diagnost & Specialty Med Expt Pathol, I-40126 Bologna, Italy

[6] Univ Bologna, Interdept Ctr L Galvani CIG, I-40126 Bologna, Italy

[7] Univ Florence, Dep Clin Expt & Biomed Sci, I-50134 Florence, Italy

[8] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

[9] Ecole Polytech Fed Lausanne, Fac Life Sci, CH-1015 Lausanne, Switzerland

[10] Aarhus Univ, Fac Sci, Interdisciplinary NanoSci Ctr iNANO, Aarhus, Denmark

来源：

AGING-US | 2014年 / 6卷 / 01期

关键词：

Healthy Aging; metabolomics; lipidomics; biomarkers; inflammageing; MINI-MENTAL-STATE; CALORIC RESTRICTION; SHOTGUN LIPIDOMICS; IMMUNE-SYSTEM; METABOLISM; PLASMA; MASS; CERAMIDE; PHOSPHATIDYLCHOLINE; ATHEROSCLEROSIS;

D O I：

10.18632/aging.100630

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot-gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.

引用

页码：9 / 25

页数：17

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