Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

被引：115

作者：

Montoliu, Ivan ^{[1
]}

Scherer, Max ^{[2
]}

Beguelin, Fiona ^{[2
]}

DaSilva, Laeticia ^{[2
]}

Mari, Daniela ^{[3
,4
]}

Salvioli, Stefano ^{[5
,6
]}

Martin, Franois-Pierre J. ^{[2
]}

Capri, Miriam ^{[5
,6
]}

Bucci, Laura ^{[5
,6
]}

Ostan, Rita ^{[5
,6
]}

Garagnani, Paolo ^{[5
,6
]}

Monti, Daniela ^{[7
]}

Biagi, Elena ^{[8
]}

Brigidi, Patrizia ^{[8
]}

Kussmann, Martin ^{[2
,9
,10
]}

Rezzi, Serge ^{[2
]}

Franceschi, Claudio ^{[5
,6
]}

Collino, Sebastiano ^{[2
]}

机构：

[1] Nestec Ltd, Nestle Res Ctr, CH-1000 Lausanne, Switzerland

[2] Nestle Inst Hlth Sci SA, Mol Biomarkers Core, CH-1015 Lausanne, Switzerland

[3] Univ Milan, Dept Med Sci, Milan, Italy

[4] Maggiore Policlin Hosp, IRCCS Ca Grande Fdn, Geriatr Unit, Milan, Italy

[5] Univ Bologna, Dept Expt Diagnost & Specialty Med Expt Pathol, I-40126 Bologna, Italy

[6] Univ Bologna, Interdept Ctr L Galvani CIG, I-40126 Bologna, Italy

[7] Univ Florence, Dep Clin Expt & Biomed Sci, I-50134 Florence, Italy

[8] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

[9] Ecole Polytech Fed Lausanne, Fac Life Sci, CH-1015 Lausanne, Switzerland

[10] Aarhus Univ, Fac Sci, Interdisciplinary NanoSci Ctr iNANO, Aarhus, Denmark

来源：

AGING-US | 2014年 / 6卷 / 01期

关键词：

Healthy Aging; metabolomics; lipidomics; biomarkers; inflammageing; MINI-MENTAL-STATE; CALORIC RESTRICTION; SHOTGUN LIPIDOMICS; IMMUNE-SYSTEM; METABOLISM; PLASMA; MASS; CERAMIDE; PHOSPHATIDYLCHOLINE; ATHEROSCLEROSIS;

D O I：

10.18632/aging.100630

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot-gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.

引用

页码：9 / 25

页数：17

共 53 条

[41] Salvioli S, 2013, CURR PHARM DESIGN, V19, P1675
[42] The immune system in extreme longevity
Sansoni, P.
Vescovini, R.
Fagnoni, F.
Biasini, C.
Zanni, F.
Zanlari, L.
Telera, A.
Lucchini, G.
Passeri, G.
Monti, D.
Franceschi, C.
Passeri, M.
[J]. EXPERIMENTAL GERONTOLOGY, 2008, 43 (02) : 61 - 65
[43] Role of redox regulation and lipid rafts in macrophages during Ox-LDL-mediated foam cell formation
Schmitz, Gerd
Grandl, Margot
[J]. ANTIOXIDANTS & REDOX SIGNALING, 2007, 9 (09) : 1499 - 1518
[44] Bottom-Up Shotgun Lipidomics by Higher Energy Collisional Dissociation on LTQ Orbitrap Mass Spectrometers
Schuhmann, Kai
Herzog, Ronny
Schwudke, Dominik
Metelmann-Strupat, Wolfgang
Bornstein, Stefan R.
Shevchenko, Andrej
[J]. ANALYTICAL CHEMISTRY, 2011, 83 (14) : 5480 - 5487
[45] Selman C., 2006, PHYSL GENOMICS
[46] Multicomponent analysis of encapsulated marine oil supplements using high-resolution 1H and 13C NMR techniques
Siddiqui, N
Sim, J
Silwood, CJL
Toms, H
Iles, RA
Grootveld, M
[J]. JOURNAL OF LIPID RESEARCH, 2003, 44 (12) : 2406 - 2427
[47] Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A
Smith, Anthony R.
Visioli, Francesco
Frei, Balz
Hagen, Tory M.
[J]. AGING CELL, 2006, 5 (05) : 391 - 400
[48] Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
Tang, W. H. Wilson
Wang, Zeneng
Levison, Bruce S.
Koeth, Robert A.
Britt, Earl B.
Fu, Xiaoming
Wu, Yuping
Hazen, Stanley L.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (17) : 1575 - 1584
[49] Anti-inflammatory actions of phosphatidylinositol
van Dieren, Jolanda M.
Simons-Oosterhuis, Ytje
Raatgeep, H. C.
Lindenbergh-Kortleve, Dicky J.
Lambers, Margaretha E. H.
van der Woude, C. Janneke
Kuipers, Ernst J.
Snoek, Gerry T.
Potman, Ron
Hammad, Hamida
Lambrecht, Bart N.
Samsom, Janneke N.
Nieuwenhuis, Edward E. S.
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (04) : 1047 - 1057
[50] Oxidative stress and the ageing endocrine system
Vitale, Giovanni
Salvioli, Stefano
Franceschi, Claudio
[J]. NATURE REVIEWS ENDOCRINOLOGY, 2013, 9 (04) : 228 - 240

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