Nitro-fatty acids: novel anti-inflammatory lipid mediators

被引：30
作者：
Rubbo, H. [1 ,2 ]
机构：
[1] Univ Republica, Fac Med, Dept Bioquim, Montevideo 11800, Uruguay
[2] Univ Republica, Fac Med, Ctr Radical & Biomed Res, Montevideo 11800, Uruguay
来源：
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 2013年 / 46卷 / 09期
关键词：
Nitro-fatty acids; Antioxidants; Nitric oxide; Inflammation; NITROLINOLEIC ACID; PPAR-GAMMA; HUMAN BLOOD; KEAP1; OXIDE; PEROXYNITRITE; ACTIVATION; NRF2; DERIVATIVES; SUPEROXIDE;
D O I：
10.1590/1414-431X20133202
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways. Here we discuss the mechanisms of nitro-fatty acid formation as well as their key chemical and biochemical properties. The electrophilic properties of nitro-fatty acids to activate anti-inflammatory signaling pathways are discussed in detail. A critical issue is the influence of nitroarachidonic acid on prostaglandin endoperoxide H synthases, redirecting arachidonic acid metabolism and signaling. We also analyze in vivo data supporting nitro-fatty acids as promising pharmacological tools to prevent inflammatory diseases.
引用
收藏
页码：728 / 734
页数：7
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