The brain through the retina: The flash electroretinogram as a tool to investigate psychiatric disorders

被引：72
作者：
Lavoie, Joelle [1 ,2 ,3 ]
Maziade, Michel [1 ,3 ]
Hebert, Marc [1 ,2 ]
机构：
[1] Inst Univ Sante Mentale Quebec, Ctr Rech, Quebec City, PQ G1J 2G3, Canada
[2] Univ Laval, Fac Med, Dept Ophthalmol Otorhinolaryngol & Cervicofacial, Quebec City, PQ G1K 7P4, Canada
[3] Univ Laval, Fac Med, Dept Psychiat & Neurosci, Quebec City, PQ G1K 7P4, Canada
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2014年 / 48卷
基金：
加拿大健康研究院;
关键词：
Biomarker; Electroretinogram; Psychiatric disorders; Retina; BLUE CONE ELECTRORETINOGRAM; COCAINE-DEPENDENT PATIENTS; OSCILLATORY POTENTIALS; BIPOLAR DISORDER; OPTIC-NERVE; DOPAMINE; SCHIZOPHRENIA; ERG; HALOPERIDOL; SEROTONIN;
D O I：
10.1016/j.pnpbp.2013.09.020
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Investigating the living brain remains one of the major obstacles in psychiatry research in order to better understand the biological underpinning of brain disorders. Novel approaches are needed to study brain functions indirectly. Since it is part of the central nervous system, retinal functions as measured with the flash electroretinogram (ERG) may reflect the central dysfunctions reported in psychiatric disorders. This review describes the flash ERG anomalies reported in patients with psychiatric disorders such as seasonal affective disorder, schizophrenia, autism spectrum disorder and drug addiction and discusses how changes in retinal functions might be used as biomarkers for psychiatric disorder as well as a potential aid to diagnosis in psychiatry. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：129 / 134
页数：6
相关论文
共 57 条
[1]   Retinal dysfunctions in schizophrenia [J].
Balogh, Zita ;
Benedek, Gyroergy ;
Keri, Szabolcs .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2008, 32 (01) :297-300
[2]   STANDARDIZED FULL-FIELD ELECTRORETINOGRAPHY - NORMAL VALUES AND THEIR VARIATION WITH AGE [J].
BIRCH, DG ;
ANDERSON, JL .
ARCHIVES OF OPHTHALMOLOGY, 1992, 110 (11) :1571-1576
[3]   THE AREA OF THE NEURORETINAL RIM OF THE OPTIC-NERVE IN NORMAL EYES [J].
BRITTON, RJ ;
DRANCE, SM ;
SCHULZER, M ;
DOUGLAS, GR ;
MAWSON, DK .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1987, 103 (04) :497-504
[4]   Assessing the impact of non-dilating the eye on full-field electroretinogram and standard flash response [J].
Gagne, A-M ;
Lavoie, J. ;
Lavoie, M-P ;
Sasseville, A. ;
Charron, M-C ;
Hebert, M. .
DOCUMENTA OPHTHALMOLOGICA, 2010, 121 (03) :167-175
[5]   ABNORMAL ELECTRORETINOGRAPHY IN SCHIZOPHRENIC-PATIENTS WITH A HISTORY OF SUN GAZING [J].
GERBALDO, H ;
THAKER, G ;
TITTEL, PG ;
LAYNEGEDGE, J ;
MORAN, M ;
DEMISCH, L .
NEUROPSYCHOBIOLOGY, 1992, 25 (02) :99-101
[6]  
GOURAS P, 1970, INVEST OPHTH VISUAL, V9, P557
[7]   Electroretinography in patients with winter seasonal affective disorder [J].
Hébert, M ;
Beattie, CW ;
Tam, EM ;
Yatham, LN ;
Lam, RW .
PSYCHIATRY RESEARCH, 2004, 127 (1-2) :27-34
[8]   Electrophysiological evidence suggesting a seasonal modulation of retinal sensitivity in subsyndromal winter depression [J].
Hébert, M ;
Dumont, M ;
Lachapelle, P .
JOURNAL OF AFFECTIVE DISORDERS, 2002, 68 (2-3) :191-202
[9]   Reproducibility of electroretinograms recorded with DTL electrodes [J].
Hebert, M ;
Lachapelle, P ;
Dumont, M .
DOCUMENTA OPHTHALMOLOGICA, 1995, 91 (04) :333-342
[10]   Retinal Response to Light in Young Nonaffected Offspring at High Genetic Risk of Neuropsychiatric Brain Disorders [J].
Hebert, Marc ;
Gagne, Anne-Marie ;
Paradis, Marie-Eve ;
Jomphe, Valerie ;
Roy, Marc-Andre ;
Merette, Chantal ;
Maziade, Michel .
BIOLOGICAL PSYCHIATRY, 2010, 67 (03) :270-274
123456