Role of Calcium sensing receptor (CaSR) in tumorigenesis

被引：38
|
作者：
Singh, Navneet [1 ,2 ]
Promkan, Moltira [3 ]
Liu, Guangming [2 ,4 ]
Varani, James [5 ]
Chakrabarty, Subhas [6 ]
机构：
[1] So Illinois Univ, Sch Med, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA
[2] Simmons Canc Inst, Springfield, IL 62794 USA
[3] Mahidol Univ, Fac Med Technol, Salaya Phuttamonthon 73170, Nakhon Pathom, Thailand
[4] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA
[5] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA
[6] So Illinois Univ, Sch Med, Springfield, IL 62794 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2013年 / 27卷 / 03期
关键词：
CaSR; colon cancer; breast cancer; differentiation; drug resistance; tumor suppressor; COLON-CARCINOMA CELLS; THYMIDYLATE SYNTHASE EXPRESSION; PROSTATE-CANCER CELLS; BREAST-CANCER; VITAMIN-D; EXTRACELLULAR CALCIUM; COLORECTAL-CANCER; ESTROGEN-RECEPTOR; DIETARY CALCIUM; BETA-CATENIN;
D O I：
10.1016/j.beem.2013.04.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The extracellular Ca2+-sensing receptor (CaSR) is a robust promoter of differentiation in colonic epithelial cells and functions as a tumor suppressor in colon cancer. CaSR mediates its biologic effects through diverse mechanisms. Loss of CaSR expression activates a myriad of stem cell-like molecular features that drive and sustain the malignant and drug-resistant phenotypes of colon cancer. This CaSR-null phenotype, however, is not irreversible and induction of CaSR expression in CaSR-null cells promotes cell death mechanisms and restores drug sensitivity. The CaSR also functions as a tumor suppressor in breast cancer and promotes cellular sensitivity to cytotoxic drugs. BRCA1 and CaSR functions intersect in breast cancer cells, and CaSR activation can rescue breast cancer cells from the deleterious effect of BRCA1 mutations. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：455 / 463
页数：9
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