Tyrosol is a quorum-sensing molecule in Candida albicans

被引：361
作者：
Chen, H
Fujita, M
Feng, QH
Clardy, J
Fink, GR
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 14期
关键词：
D O I：
10.1073/pnas.0401416101
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human fungal pathogen Candida albicans shows a significant lag in growth when diluted into fresh minimal medium. This lag is abolished by the addition of conditioned medium from a high-density culture. The active component of conditioned medium is tyrosol, which is released into the medium continuously during growth. Under conditions permissive for germ-tube formation, tyrosol stimulates the formation of these filamentous protrusions. Because germ-tube formation is inhibited by farnesol, another quorum-sensing molecule, this process must be under complex positive and negative control by environmental conditions. The identification of tyrosol as an autoregulatory molecule has important implications on the dynamics of growth and morphogenesis in Candida.
引用
收藏
页码：5048 / 5052
页数：5
相关论文
共 20 条
[1]  
[Anonymous], 1988, CANDIDA CANDIDIASIS
[2]   Small talk: Cell-to-cell communication in bacteria [J].
Bassler, BL .
CELL, 2002, 109 (04) :421-424
[3]  
BECKSAGUE CM, 1993, J INFECT DIS, V167, P1247, DOI 10.1093/infdis/167.5.1247
[4]   2,4-(hydroxyphenyl)-ethanol, an antioxidative agent produced by Candida spp., impairs neutrophilic yeast killing in vitro [J].
Cremer, J ;
Vatou, V ;
Braveny, I .
FEMS MICROBIOLOGY LETTERS, 1999, 170 (02) :319-325
[5]   Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol [J].
Hornby, JM ;
Jensen, EC ;
Lisec, AD ;
Tasto, JJ ;
Jahnke, B ;
Shoemaker, R ;
Dussault, P ;
Nickerson, KW .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2001, 67 (07) :2982-2992
[6]   Bacterial dormancy and culturability: the role of autocrine growth factors - Commentary [J].
Kell, DB ;
Young, M .
CURRENT OPINION IN MICROBIOLOGY, 2000, 3 (03) :238-243
[7]   The glyoxylate cycle is required for fungal virulence [J].
Lorenz, MC ;
Fink, GR .
NATURE, 2001, 412 (6842) :83-86
[8]   Quorum sensing in bacteria [J].
Miller, MB ;
Bassler, BL .
ANNUAL REVIEW OF MICROBIOLOGY, 2001, 55 :165-199
[9]   A bacterial cytokine [J].
Mukamolova, GV ;
Kaprelyants, AS ;
Young, DI ;
Young, M ;
Kell, DB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8916-8921
[10]   Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition [J].
Nantel, A ;
Dignard, D ;
Bachewich, C ;
Harcus, D ;
Marcil, A ;
Bouin, AP ;
Sensen, CW ;
Hogues, H ;
van het Hoog, M ;
Gordon, P ;
Rigby, T ;
Benoit, F ;
Tessier, DC ;
Thomas, DY ;
Whiteway, M .
MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (10) :3452-3465
12