Qi-Shen-Yi-Qi Dripping Pills for the Secondary Prevention of Myocardial Infarction: A Randomised Clinical Trial

被引：51

作者：

Shang, Hongcai ^{[1
]}

Zhang, Junhua ^{[1
]}

Yao, Chen ^{[2
]}

Liu, Baoyan ^{[3
]}

Gao, Xiumei ^{[1
]}

Ren, Ming ^{[1
]}

Cao, Hongbao ^{[1
]}

Dai, Guohua ^{[4
]}

Weng, Weiliang ^{[5
]}

Zhu, Sainan ^{[2
]}

Wang, Hui ^{[1
]}

Xu, Hongjuan ^{[1
]}

Zhang, Boli ^{[1
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China

[2] Peking Univ First Hosp, Beijing 100034, Peoples R China

[3] Chinese Acad Tradit Chinese Med, Beijing 100700, Peoples R China

[4] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan 250011, Shandong, Peoples R China

[5] Xiyuan Hosp, Beijing 100091, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷

关键词：

CARDIOVASCULAR-DISEASE; ANTIPLATELET TARGETS; ASPIRIN RESISTANCE; RISK; ASSOCIATION; POLYCAP; DEATH;

D O I：

10.1155/2013/738391

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background. Several types of drugs have been recommended for the secondary prevention of myocardial infarction (MI). However, these conventional strategies have several limitations, such as low adherence, high cost, and side effects during long time use. Novel approaches to this problem are still needed. This trial aimed to test the effectiveness and safety of Qi-Shen-Yi-Qi Dripping Pills (QSYQ), a multi-ingredient Chinese patent medicine, for the secondary prevention of MI. Methods and Findings. A total of 3505 eligible patients were randomly assigned to QSYQ group (1746 patients) or aspirin group (1759). Patients took their treatments for 12 months. The final follow-up visit took place 6 months after the end of the trial drugs. The 12-month and 18-month estimated incidences of the primary outcome were 2.98% and 3.67%, respectively, in the QSYQ group. The figures were 2.96% and 3.81% in the aspirin group. No significant difference was identified between the groups. Conclusions. This trial did not show significant difference of primary and secondary outcomes between aspirin and QSYQ in patients who have had an MI. Though inconclusive, the result suggests that QSYQ has similar effects to aspirin in the secondary prevention of MI.

引用

页数：9

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