Sustained drug release from an ultrathin hydrogel film

被引：25
|
作者：
Zhu, Weipu [1 ]
Xiong, Lu [1 ]
Wang, Huan [1 ]
Zha, Guangyu [2 ]
Du, Hong [1 ]
Li, Xiaodong [2 ]
Shen, Zhiquan [1 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Stomatol Hosp, Hangzhou 310006, Zhejiang, Peoples R China
来源：
POLYMER CHEMISTRY | 2015年 / 6卷 / 40期
基金：
中国国家自然科学基金;
关键词：
BY-LAYER FILMS; CLICK CHEMISTRY; MULTILAYER HYDROGELS; PH; FABRICATION;
D O I：
10.1039/c5py01204j
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
We reported a facile method to prepare camptothecin (CPT) loaded ultrathin hydrogel films based on a polymeric prodrug via layer by layer (LbL) thiol-ene "click" chemistry. Free camptothecin could be sustainedly released from the ultrathin hydrogel film within 24 hours through the hydrolysis of ester bonds between the hydrogel backbone and the camptothecin moieties.
引用
收藏
页码：7097 / 7099
页数：3
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