Sustained drug release from an ultrathin hydrogel film

被引：25
|
作者：
Zhu, Weipu [1 ]
Xiong, Lu [1 ]
Wang, Huan [1 ]
Zha, Guangyu [2 ]
Du, Hong [1 ]
Li, Xiaodong [2 ]
Shen, Zhiquan [1 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Stomatol Hosp, Hangzhou 310006, Zhejiang, Peoples R China
来源：
POLYMER CHEMISTRY | 2015年 / 6卷 / 40期
基金：
中国国家自然科学基金;
关键词：
BY-LAYER FILMS; CLICK CHEMISTRY; MULTILAYER HYDROGELS; PH; FABRICATION;
D O I：
10.1039/c5py01204j
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
We reported a facile method to prepare camptothecin (CPT) loaded ultrathin hydrogel films based on a polymeric prodrug via layer by layer (LbL) thiol-ene "click" chemistry. Free camptothecin could be sustainedly released from the ultrathin hydrogel film within 24 hours through the hydrolysis of ester bonds between the hydrogel backbone and the camptothecin moieties.
引用
收藏
页码：7097 / 7099
页数：3
相关论文
共 50 条
  • [21] Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release
    Hou Bing-na
    Li Jin
    Ni Kai
    Han Chao-yue
    Shen Hui-ling
    Zhao Lin-lin
    Li Zheng-zheng
    CAILIAO GONGCHENG-JOURNAL OF MATERIALS ENGINEERING, 2020, 48 (11): : 76 - 84
  • [22] Sustained Release of Bevacizumab from Hydrogel Depots for Intravitreal Injections
    Elhayek, Rami F.
    Sawhney, Amarpreet
    Jarrett, Peter
    Guedez, Sarah
    Rosales, Courtney
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
  • [23] Sustained Drug Release from Contact Lenses
    Ferreira, J. A.
    Oliveira, P.
    Silva, P. M.
    Carreira, A.
    Gil, H.
    Murta, J. N.
    CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES, 2010, 60 (02): : 151 - 179
  • [24] Sustained drug release from contact lenses
    Ferreira, J.A.
    Oliveira, P.
    Silva, P.M.
    Carreira, A.
    Gil, H.
    Murta, J.N.
    CMES - Computer Modeling in Engineering and Sciences, 2010, 60 (02): : 151 - 179
  • [25] Drug release from new bioartificial hydrogel
    Artif Cells Blood Substitutes Immobilization Biotechnol, 5 (605):
  • [26] Sustained release of an antitumoral drug from alginate-chitosan hydrogel beads and its potential use as colonic drug delivery
    Torelli-Souza, Rebecca R.
    Cavalcante Bastos, Layanna A.
    Nunes, Hermano G. L.
    Camara, Celso A.
    Amorim, Rosa Valeria S.
    JOURNAL OF APPLIED POLYMER SCIENCE, 2012, 126 : E408 - E417
  • [27] Surface modified thin film from silk and gelatin for sustained drug release to heal wound
    Alam, A. K. M. Moshiul
    Shubhra, Quazi T. H.
    JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (31) : 6473 - 6479
  • [28] Silk Fibroin Hydrogel Reinforced With Magnetic Nanoparticles as an Intelligent Drug Delivery System for Sustained Drug Release
    Haghighattalab, Mahsa
    Kajbafzadeh, Abdolmohammad
    Baghani, Mostafa
    Gharehnazifam, Ziba
    Jobani, Bahareh Mohammadi
    Baniassadi, Majid
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 10
  • [29] Preparation of heptanoylated glycol chitosan thermo-sensitive hydrogel for sustained drug release
    Han X.
    Li Z.
    Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica, 2024, 41 (05): : 2674 - 2682
  • [30] Thermosensitive hydrogel based on chitosan-gelatin and used for sustained drug release in vitro
    Lin, Y.-W., 1600, Journal of Functional Materials, P.O. Box 1512, Chongqing, 630700, China (44):
12345