Bis-sesquiterpenes and diterpenes from Chloranthus henryi

被引：93

作者：

Li, Chuang-Jun ^{[1
,2
,3
]}

Zhang, Dong-Ming ^{[1
,2
]}

Luo, Yong-Ming ^{[3
]}

Yu, Shi-Shan ^{[1
,2
]}

Li, Yan ^{[1
,2
]}

Lu, Yang ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Jiangxi Univ Tradit Chinese Med, Fac Pharm, Nanchang 330006, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Chloranthus henryi; Chloranthaceae; Bis-sesquiterpenes; Diterpenes; Henriols; Henrilabdanes; Hepatoprotective cytotoxicity;

D O I：

10.1016/j.phytochem.2008.08.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bis-sesquiterpenes, henriols A (1), B (2), C (3), and D (4), and three diterpenes, henrilabdanes A (5), B (6), and C (7), together with two known bis-sesquiterpenes and three known labdane diterpenes, were isolated from the ethanol extract of the roots of Chloranthus henryi. Their structures and absolute configurations were elucidated by NMR spectroscopic, X-ray crystallographic and CD analyses. Compounds 1, 5, 6 and 7 showed moderate hepatoprotective activities with IC50 values of 0.19, 0.66, 0.09 and 0.18 mu m, respectively. They were not studied further due to the weak effects noted. Compounds 3 and 8 exhibited cytotoxic activities against three types of cancer cell lines including the hepatoma (BEL7402), human gastric carcinoma (BGC-823), and colon cancer (HCT-8). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2867 / 2874

页数：8

共 23 条

[1]

CARMICHAEL J, 1987, CANCER RES, V47, P936

[2]

FANG JM, 1993, PHYTOCHEMISTRY, V34, P1581, DOI 10.1016/S0031-9422(00)90849-5

[3] 12,15-DIHYDROXYLABDA-8(17),13-DIEN-19-OIC ACID FROM GUIZOTIA-SCABRA [J].