Effects of Schedule I drug laws on neuroscience research and treatment innovation

被引:216
作者
Nutt, David J. [1 ]
King, Leslie A. [2 ]
Nichols, David E. [3 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Ctr Neuropsychopharmacol, Div Brain Sci, London W12 0NN, England
[2] Forens Sci Serv Inc, Drugs Intelligence Unit, London SE1 7LP, England
[3] Univ N Carolina, Eschelman Sch Pharm, Chapel Hill, NC 27514 USA
基金
英国医学研究理事会;
关键词
MYSTICAL-TYPE EXPERIENCES; ACID DIETHYLAMIDE; CLUSTER HEADACHE; PSILOCYBIN; CANNABIS; SYMPTOMS; DELTA(9)-TETRAHYDROCANNABINOL; PSYCHOTHERAPY; KETAMINE; EFFICACY;
D O I
10.1038/nrn3530
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Many psychoactive drugs are used recreationally, particularly by young people. This use and its perceived dangers have led to many different classes of drugs being banned under national laws and international conventions. Indeed, the possession of cannabis, 3,4-methylenedioxy-N-methylamphetamine (MDMA; also known as ecstasy) and psychedelics is stringently regulated. An important and unfortunate outcome of the controls placed on these and other psychoactive drugs is that they make research into their mechanisms of action and potential therapeutic uses - for example, in depression and post-traumatic stress disorder - difficult and in many cases almost impossible.
引用
收藏
页码:577 / 585
页数:9
相关论文
共 69 条
[1]   Cannabis in painful HIV-associated sensory neuropathy - A randomized placebo-controlled trial [J].
Abrams, D. I. ;
Jay, C. A. ;
Shade, S. B. ;
Vizoso, H. ;
Reda, H. ;
Press, S. ;
Kelly, M. E. ;
Rowbotham, M. C. ;
Petersen, K. L. .
NEUROLOGY, 2007, 68 (07) :515-521
[2]  
Advisory Council on the Misuse of Drugs, 2008, CANN CLASS PUBL HLTH
[3]   Serotonergic regulation of neuronal excitability in the prefrontal cortex [J].
Andrade, Rodrigo .
NEUROPHARMACOLOGY, 2011, 61 (03) :382-386
[4]  
[Anonymous], 2008, PRISONS DRUG OFFENDE
[5]   Is Ecstasy an "Empathogen"? Effects of ±3,4-Methylenedioxymethamphetamine on Prosocial Feelings and Identification of Emotional States in Others [J].
Bedi, Gillinder ;
Hyman, David ;
de Wit, Harriet .
BIOLOGICAL PSYCHIATRY, 2010, 68 (12) :1134-1140
[6]   Effects of MDMA on sociability and neural response to social threat and social reward [J].
Bedi, Gillinder ;
Phan, K. Luan ;
Angstadt, Mike ;
de Wit, Harriet .
PSYCHOPHARMACOLOGY, 2009, 207 (01) :73-83
[7]  
Bird S, 2011, STRAIGHT STAT
[8]   Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin [J].
Carhart-Harris, R. L. ;
Leech, R. ;
Williams, T. M. ;
Erritzoe, D. ;
Abbasi, N. ;
Bargiotas, T. ;
Hobden, P. ;
Sharp, D. J. ;
Evans, J. ;
Feilding, A. ;
Wise, R. G. ;
Nutt, D. J. .
BRITISH JOURNAL OF PSYCHIATRY, 2012, 200 (03) :238-244
[9]  
Carhart-Harris R. L., 2012, SCHIZOPHR B, DOI [10.1093/schbul/sbs117, DOI 10.1093/SCHBUL/SBS117)]
[10]  
Carhart-Harris R. L, 2013, BR NEUROSCI ASS ABST, V22