Naturally Acquired Human Plasmodium cynomolgi and P. knowlesi Infections, Malaysian Borneo

被引:56
作者
Raja, Thamayanthi Nada [1 ]
Hu, Ting Huey [1 ]
Kadir, Khamisah Abdul [1 ]
Mohamad, Dayang Shuaisah Awang [1 ]
Rosli, Nawal [1 ]
Wong, Lolita Lin [1 ]
Hii, King Ching [2 ]
Divis, Paul Cliff Simon [1 ]
Singh, Balbir [1 ]
机构
[1] Univ Malaysia Sarawak, Malaria Res Ctr, Kota Samarahan 94300, Sarawak, Malaysia
[2] Kapit Hosp, Kapit, Malaysia
关键词
MALARIA PARASITES;
D O I
10.3201/eid2608.200343
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013-December 31, 2017. Using nested PCR assays, we found 845 (80.6%) patients had either P. knowlesi monoinfection (n = 815) or co-infection with other Plasmodium species (n = 30). We noted the annual number of these zoonotic infections increased greatly in 2017 (n = 284). We identified 6 patients, 17-65 years of age, with P. cynomolgi and P. knowlesi co-infections, confirmed by phylogenetic analyses of the Plasmodium cytochrome c oxidase subunit 1 gene sequences. P. knowlesi continues to be a public health concern in the Kapit Division of Sarawak, Malaysian Borneo. In addition, another simian malaria parasite, P. cynomolgi, also is an emerging cause of malaria in humans.
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收藏
页码:1801 / 1809
页数:9
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