Improving hematopoietic engraftment: Potential role of mesenchymal stromal cell-derived extracellular vesicles

被引：17

作者：

Preciado, Silvia ^{[1
,2
,3
,4
,5
]}

Muntion, Sandra ^{[1
,2
,3
,4
,5
]}

Sanchez-Guijo, Fermin ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] IBSAL Hosp Univ Salamanca, Area Terapia Celular, Paseo San Vicente 58-182, Salamanca 37007, Spain

[2] IBSAL Hosp Univ Salamanca, Serv Hematol, Salamanca, Spain

[3] Ctr Red Med Regenerat & Terapia Celular Castilla, Salamanca, Spain

[4] RETIC TerCel, Madrid, Spain

[5] ISCIII, CIBERONC, Madrid, Spain

[6] Univ Salamanca, Ctr Invest Canc, Salamanca, Spain

[7] Univ Salamanca, Dept Med, Salamanca, Spain

来源：

STEM CELLS | 2021年 / 39卷 / 01期

关键词：

engraftment; exosomes; extracellular vesicles; graft failure; hematopoietic stem cell transplantation; hematopoietic stem cells; mesenchymal stromal cells; microvesicles; poor graft function; STEM-CELLS; DIFFERENTIATION; EXOSOMES; THERAPY; IRRADIATION; MICRORNAS; SURVIVAL;

D O I：

10.1002/stem.3278

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The therapeutic effects of mesenchymal stromal cells (MSCs) in graft failure or poor graft function after allogenic hematopoietic stem cell transplantation (HSCT) are currently undergoing clinical evaluation. MSCs exert their functions, at least partially, through the secretion of extracellular vesicles (MSC-EVs). The available information on the biological potential of MSC-EVs to improve hematopoietic function, both in in vitro studies and in reported preclinical models, focusing on the possible mechanisms of these effects are summarized in the current review. The potential advantages of EVs over MSCs are also discussed, as well as the limitations and uncertainties in terms of isolation, characterization, mechanism of action in this setting, and industrial scalability that should be addressed for their potential clinical application.

引用

页码：26 / 32

页数：7

共 65 条

[1] Bone Marrow-Derived Mesenchymal Stromal Cells Harness Purinergenic Signaling to Tolerize Human Th1 Cells In Vivo [J].

Amarnath, Shoba ;

Foley, Jason E. ;

Farthing, Don E. ;

Gress, Ronald E. ;

Laurence, Arian ;

Eckhaus, Michael A. ;

Metais, Jean-Yves ;

Rose, Jeremy J. ;

Hakim, Frances T. ;

Felizardo, Tania C. ;

Cheng, Austin V. ;

Robey, Pamela G. ;

Stroncek, David E. ;

Sabatino, Marianna ;

Battiwalla, Minoo ;

Ito, Sawa ;

Fowler, Daniel H. ;

Barrett, Austin J. .

STEM CELLS, 2015, 33 (04) :1200-1212

[2] Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles [J].

Arasu, Uma Thanigai ;

Karna, Riikka ;

Harkonen, Kai ;

Oikari, Sanna ;

Koistinen, Arto ;

Kroger, Heikki ;

Qu, Chengjuan ;

Lammi, Mikko J. ;

Rilla, Kirsi .

MATRIX BIOLOGY, 2017, 64 :54-68

[3] Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species [J].

Baglio, Serena Rubina ;

Rooijers, Koos ;

Koppers-Lalic, Danijela ;

Verweij, Frederik J. ;

Lanzon, M. Perez ;

Zini, Nicoletta ;

Naaijkens, Benno ;

Perut, Francesca ;

Niessen, Hans W. M. ;

Baldini, Nicola ;

Pegtel, D. Michiel .

STEM CELL RESEARCH & THERAPY, 2015, 6

[4] The Role of Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles (MSC-EVs) in Normal and Abnormal Hematopoiesis and Their Therapeutic Potential [J].

Batsali, Aristea K. ;

Georgopoulou, Anthie ;

Mavroudi, Irene ;

Matheakakis, Angelos ;

Pontikoglou, Charalampos G. ;

Papadaki, Helen A. .

JOURNAL OF CLINICAL MEDICINE, 2020, 9 (03)

[5]

Budoni M, 2013, CELL TRANSPLANT, V22, P369, DOI 10.3727/096368911X582769

[6] Effects of MSC Coadministration and Route of Delivery on Cord Blood Hematopoietic Stem Cell Engraftment [J].

Carrancio, S. ;

Romo, C. ;

Ramos, T. ;

Lopez-Holgado, N. ;

Muntion, S. ;

Prins, H. J. ;

Martens, A. C. ;

Brinon, J. G. ;

San Miguel, J. F. ;

del Canizo, M. C. ;

Sanchez-Guijo, F. .

CELL TRANSPLANTATION, 2013, 22 (07) :1171-1183

[7] Bone Marrow Mesenchymal Stem Cells for Improving Hematopoietic Function: An In Vitro and In Vivo Model. Part 2: Effect on Bone Marrow Microenvironment [J].

Carrancio, Soraya ;

Blanco, Belen ;

Romo, Carlos ;

Muntion, Sandra ;

Lopez-Holgado, Natalia ;

Blanco, Juan F. ;

Brinon, Jesus G. ;

San Miguel, Jesus F. ;

Sanchez-Guijo, Fermin M. ;

Consuelo del Canizo, M. .

PLOS ONE, 2011, 6 (10)

[8] Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs [J].

Chen, Tian Sheng ;

Arslan, Fatih ;

Yin, Yijun ;

Tan, Soon Sim ;

Lai, Ruenn Chai ;

Choo, Andre Boon Hwa ;

Padmanabhan, Jayanthi ;

Lee, Chuen Neng ;

de Kleijn, Dominique P. V. ;

Lim, Sai Kiang .

JOURNAL OF TRANSLATIONAL MEDICINE, 2011, 9

[9] Immunomodulatory effects of mesenchymal stromal cells-derived exosome [J].

Chen, Wancheng ;

Huang, Yukai ;

Han, Jiaochan ;

Yu, Lili ;

Li, Yanli ;

Lu, Ziyuan ;

Li, Hongbo ;

Liu, Zenghui ;

Shi, Chenyan ;

Duan, Fengqi ;

Xiao, Yang .

IMMUNOLOGIC RESEARCH, 2016, 64 (04) :831-840

[10] Emerging Role of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Pathogenesis of Haematological Malignancies [J].

Cominal, Jucara Gastaldi ;

Cacemiro, Maira da Costa ;

Pinto-Simoes, Belinda ;

Kolb, Hans-Jochem ;

Ribeiro Malmegrim, Kelen Cristina ;

de Castro, Fabiola Attie .

STEM CELLS INTERNATIONAL, 2019, 2019

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