Imaging of glutamate neurotransmitter alterations in Alzheimer's disease

被引：115

作者：

Haris, Mohammad ^{[1
]}

Nath, Kavindra ^{[2
]}

Cai, Kejia ^{[1
]}

Singh, Anup ^{[1
]}

Crescenzi, Rachelle ^{[1
]}

Kogan, Feliks ^{[1
]}

Verma, Gaurav ^{[2
]}

Reddy, Sanjana ^{[1
]}

Hariharan, Hari ^{[1
]}

Melhem, Elias R. ^{[2
]}

Reddy, Ravinder ^{[1
]}

机构：

[1] Univ Penn, Dept Radiol, Ctr Magnet Resonance & Opt Imaging, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

来源：

NMR IN BIOMEDICINE | 2013年 / 26卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; brain; glutamate; MRS; MRI; chemical exchange saturation transfer imaging; IN-VIVO; COGNITIVE IMPAIRMENT; EARLY-DIAGNOSIS; SPECTROSCOPY;

D O I：

10.1002/nbm.2875

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Glutamate (Glu) is a major excitatory neurotransmitter in the brain and has been shown to decrease in the early stages of Alzheimer's disease (AD). Using a glutamate chemical (amine) exchange saturation transfer (GluCEST) method, we imaged the change in [Glu] in the APP-PS1 transgenic mouse model of AD at high spatial resolution. Compared with wild-type controls, AD mice exhibited a notable reduction in GluCEST contrast (similar to 30%) in all areas of the brain. The change in [Glu] was further validated through 1H MRS. A positive correlation was observed between GluCEST contrast and 1H MRS-measured Glu/total creatine ratio. This method potentially provides a novel noninvasive biomarker for the diagnosis of the disease in preclinical stages and enables the development of disease-modifying therapies for AD. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

页码：386 / 391

页数：6

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