Effects of mushroom, Pleurotus eryngii, extracts on bone metabolism

被引：25
|
作者：
Kim, SW
Kim, HG
Lee, BE
Hwang, HH
Baek, DH
Ko, SY
机构：
[1] Oscotec Inc, Choongnam 330831, South Korea
[2] Dankook Univ, Dept Dent Pharmacol, Cheonan, South Korea
[3] Dankook Univ, Dept Pharmacol, Cheonan, South Korea
[4] Dankook Univ, Dept Oral Microbiol & Immunol, Cheonan, South Korea
[5] Dankook Univ, Sch Dent, Dept Oral Biochem, Cheonan 330714, South Korea
来源：
CLINICAL NUTRITION | 2006年 / 25卷 / 01期
关键词：
Pleurotus eryngii; osteoclast; osteoblast; ovariectomy; bone mineral density;
D O I：
10.1016/j.clnu.2005.10.014
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
We performed the present study to investigate whether Pleurotus eryngii extracts (PEX) play a role in bone metabolism. PEX treatment showed increase in the alkaline phosphatase activity of the osteoblasts and in the osteocalcin mRNA expression from primary osteoblasts. PEX also increased the expression of the Runx2 gene, and the secretion of osteoprotegerin from the osteoblasts showed marked increases after treatment with PEX. In addition, PEX treatment decreased the number of tartrate-resistant acid phosphatase (TRAP)positive multinucleated cells and resorption areas. In vivo studies, using rats with ovariectomy-induced osteoporosis revealed that PEX alleviated the decrease in the trabecular bond mineral density. (c) 2005 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
引用
收藏
页码：166 / 170
页数：5
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