Aged garlic extract protects against methotrexate-induced apoptotic cell injury of IEC-6 cells

被引：21

作者：

Horie, T ^{[1
]}

Li, T ^{[1
]}

Ito, K ^{[1
]}

Sumi, S ^{[1
]}

Fuwa, T ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chiba, Japan

来源：

JOURNAL OF NUTRITION | 2006年 / 136卷 / 03期

关键词：

aged garlic extract; methotrexate; IEC-6; cells; intestinal damage;

D O I：

10.1093/jn/136.3.861S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Gastrointestinal toxicity is one of the most serious side effects of methotrexate (MTX) treatment. The side effects often disrupt the cancer chemotherapy. We previously reported that aged garlic extract (AGE) protects the small intestine of rats from MTX-induced damage. In this study, the protection of AGE against MTX-induced damage of IEC-6 cells originating from the rat jejunum crypt was investigated. MTX decreased the viability of IEC-6 cells, but this effect was prevented by AGE (0.5%). The MTX-induced apoptosis of IEC-6 cells was depressed by AGE. These results indicated that AGE protects IEC-6 cells from the MTX-induced damage. AGE may be useful in cancer chemotherapy with MTX because it reduces MTX-induced intestinal damage.

引用

页码：861S / 863S

页数：3

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