Chromatin Insulators: Regulatory Mechanisms and Epigenetic Inheritance

被引：147

作者：

Bushey, Ashley M. ^{[1
,2
]}

Dorman, Elizabeth R. ^{[1
,2
]}

Corces, Victor G. ^{[1
]}

机构：

[1] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

[2] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA

来源：

MOLECULAR CELL | 2008年 / 32卷 / 01期

关键词：

D O I：

10.1016/j.molcel.2008.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enhancer-blocking insulators are DNA elements that disrupt the communication between a regulatory sequence, such as an enhancer or a silencer, and a promoter. Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are many regulatory mechanisms in place that enhance or hinder insulator activity. These modes of regulation could be used to establish cell-type-specific insulator activity that is epigenetically inherited along a cell and/or organismal lineage. This review will discuss the evidence for epigenetic inheritance and regulation of insulator function.

引用

页码：1 / 9

页数：9

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