Total Synthesis and Complete Stereostructure of Gambieric Acid A

被引：50

作者：

Fuwa, Haruhiko ^{[1
]}

Ishigai, Kazuya ^{[1
]}

Hashizume, Keisuke ^{[1
]}

Sasaki, Makoto ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Life Sci, Aoba Ku, Sendai, Miyagi 9808577, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 29期

关键词：

ANTIFUNGAL POLYCYCLIC ETHERS; STEREOSELECTIVE-SYNTHESIS; STEREOCONTROLLED SYNTHESIS; ABSOLUTE-CONFIGURATION; CONVERGENT SYNTHESIS; RING FRAGMENT; BIOLOGICAL-ACTIVITIES; POLYETHER CORE; EFGH-RING; CONSTRUCTION;

D O I：

10.1021/ja305864z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Total synthesis of gambieric acid A, a potent antifungal polycyclic ether metabolite, has been accomplished for the first time, which firmly established the complete stereostructure of this natural product.

引用

页码：11984 / 11987

页数：4

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