Preclinical Assessment of a Zwitterionic Tantalum Oxide Nanoparticle X-ray Contrast Agent

被引：74

作者：

Bonitatibus, Peter J., Jr. ^{[1
]}

Torres, Andrew S. ^{[1
]}

Kandapallil, Binil ^{[1
]}

Lee, Brian D. ^{[1
]}

Goddard, Greg D. ^{[1
]}

Colborn, Robert E. ^{[1
]}

Marino, Michael E. ^{[1
]}

机构：

[1] GE Global Res Ctr, Niskayuna, NY 12309 USA

来源：

ACS NANO | 2012年 / 6卷 / 08期

关键词：

tantalum oxide; nanoparticle; X-ray contrast; zwitterion; GOLD NANOPARTICLES; QUANTUM DOTS; IMIDAZOLIUM SULFONATE; SILICA NANOPARTICLES; SURFACE; FUNCTIONALIZATION; PHOSPHORYLCHOLINE; MONOLAYERS; ENDOTOXIN; CYSTEINE;

D O I：

10.1021/nn300928g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tantalum oxide nanoparticles show great potential as the next generation of X-ray contrast media. Recently, we reported advances in tantalum oxide nanoparticles and identified improvements that were required for such particles to progress further. Namely, the viscosity of concentrated particles, the amount of retention in reticuloendothelial (RES) tissues, and the effect of large quantities of particles on the kidneys after administration were all identified as critical factors which needed further study, understanding, and development. Here, we report on a zwitterionic siloxane polymer nanopartide coating that reduced the viscosity of concentrated solutions of particles by a factor of 5, decreased tissue retention of Injected particles by a factor of 10, and, importantly, did not induce pathological responses in the kidneys.

引用

页码：6650 / 6658

页数：9

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