Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer

被引:11
作者
Lafont, Elodie [1 ,2 ]
机构
[1] Univ Rennes, INSERM, U1242, F-35042 Rennes, France
[2] Ctr Lutte Canc Eugene Marquis, F-35042 Rennes, France
关键词
death receptor; ER stress; unfolded protein response; TRAIL-R1; 2; CD95; TNFR1; post-translational modifications; cell death; IRE1; PERK; TUMOR-NECROSIS-FACTOR; ENDOPLASMIC-RETICULUM STRESS; APOPTOSIS-INDUCING LIGAND; NF-KAPPA-B; TRAIL-INDUCED APOPTOSIS; ISOLATED LIMB PERFUSION; SOLUBLE FAS LIGAND; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; HUMAN-MELANOMA CELLS; ER-STRESS;
D O I
10.3390/cancers12051113
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses that both regulate a plethora of outcomes, ranging from proliferation, differentiation, migration, cytokine production to the induction of cell death. Both signallings are major modulators of physiological tissue homeostasis and their dysregulation is involved in tumorigenesis and the metastastic process. The molecular determinants of the control between the different cellular outcomes induced by DR signalling and the UPR in tumour cells and their stroma and their consequences on tumorigenesis are starting to be unravelled. Herein, I summarize the main steps of DR signalling in relation to its cellular and pathophysiological roles in cancer. I then highlight how the UPR and DR signalling control common cellular outcomes and also cross-talk, providing potential opportunities to further understand the development of malignancies.
引用
收藏
页数:32
相关论文
共 298 条
  • [1] Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity
    Aaes, Tania Love
    Kaczmarek, Agnieszka
    Delvaeye, Tinneke
    De Craene, Bram
    De Koker, Stefaan
    Heyndrickx, Liesbeth
    Delrue, Iris
    Taminau, Joachim
    Wiernicki, Bartosz
    De Groote, Philippe
    Garg, Abhishek D.
    Leybaert, Luc
    Grooten, Johan
    Bertrand, Mathieu J. M.
    Agostinis, Patrizia
    Berx, Geert
    Declercq, Wim
    Vandenabeele, Peter
    Krysko, Dmitri V.
    [J]. CELL REPORTS, 2016, 15 (02): : 274 - 287
  • [2] Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress
    Abhari, Behnaz Ahangarian
    McCarthy, Nicole
    Le Berre, Marie
    Kilcoyne, Michelle
    Joshi, Lokesh
    Agostinis, Patrizia
    Fulda, Simone
    [J]. CELL DEATH & DISEASE, 2019, 10 (3)
  • [3] Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas
    Afshar-Sterle, Shoukat
    Zotos, Dimitra
    Bernard, Nicholas J.
    Scherger, Anna K.
    Roedling, Lisa
    Alsop, Amber E.
    Walker, Jennifer
    Masson, Frederick
    Belz, Gabrielle T.
    Corcoran, Lynn M.
    O'Reilly, Lorraine A.
    Strasser, Andreas
    Smyth, Mark J.
    Johnstone, Ricky
    Tarlinton, David M.
    Nutt, Stephen L.
    Kallies, Axel
    [J]. NATURE MEDICINE, 2014, 20 (03) : 283 - 290
  • [4] Death Receptors and Their Ligands in Inflammatory Disease and Cancer
    Annibaldi, Alessandro
    Walczak, Henning
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2020, 12 (09): : 1 - 19
  • [5] Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
    Annibaldi, Alessandro
    John, Sidonie Wicky
    Berghe, Tom Vanden
    Swatek, Kirby N.
    Ruan, Jianbin
    Liccardi, Gianmaria
    Bianchi, Katiuscia
    Elliott, Paul R.
    Choi, Sze Men
    Van Coillie, Samya
    Bertin, John
    Wu, Hao
    Komander, David
    Vandenabeele, Peter
    Silke, John
    Meier, Pascal
    [J]. MOLECULAR CELL, 2018, 69 (04) : 566 - +
  • [6] Safety and antitumor activity of recombinant soluble Apo2 ligand
    Ashkenazi, A
    Pai, RC
    Fong, S
    Leung, S
    Lawrence, DA
    Masters, SA
    Blackie, C
    Chang, L
    McMurtrey, AE
    Hebert, A
    DeForge, L
    Koumenis, IL
    Lewis, D
    Harris, L
    Bussiere, J
    Koeppen, H
    Shahrokh, Z
    Schwall, RH
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) : 155 - 162
  • [7] Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells
    Azijli, Kaamar
    Yuvaraj, Saravanan
    Peppelenbosch, Maikel P.
    Wurdinger, Thomas
    Dekker, Henk
    Joore, Jos
    van Dijk, Evert
    Quax, Wim J.
    Peters, Godefridus J.
    de Jong, Steven
    Kruyt, Frank A. E.
    [J]. JOURNAL OF CELL SCIENCE, 2012, 125 (19) : 4651 - 4661
  • [8] Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis
    Bajou, Khalid
    Peng, Hongjun
    Laug, Walter E.
    Maillard, Catherine
    Noel, Agnes
    Foidart, Jean M.
    Martial, Joseph A.
    DeClerck, Yves A.
    [J]. CANCER CELL, 2008, 14 (04) : 324 - 334
  • [9] Tumour necrosis factor and cancer
    Balkwill, Frances
    [J]. NATURE REVIEWS CANCER, 2009, 9 (05) : 361 - 371
  • [10] 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival
    Balta, Guelce S. Guelcueler
    Monzel, Cornelia
    Kleber, Susanne
    Beaudouin, Joel
    Balta, Emre
    Kaindl, Thomas
    Chen, Si
    Gao, Liang
    Thiemann, Meinolf
    Wirtz, Christian R.
    Samstag, Yvonne
    Tanaka, Motomu
    Martin-Villalba, Ana
    [J]. CELL REPORTS, 2019, 29 (08): : 2295 - +