Lessons learned from HIV-1 vaccine trials: new priorities and directions

被引：72

作者：

McMichael, Andrew J. ^{[1
]}

Haynes, Barton F. ^{[2
,3
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DU, England

[2] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC USA

[3] Duke Univ, Sch Med, Dept Med, Ctr HIV AIDS Vaccine Immunol, Durham, NC 27706 USA

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 05期

基金：

英国医学研究理事会;

关键词：

HUMAN MONOCLONAL-ANTIBODIES; NEUTRALIZING ANTIBODIES; STRUCTURAL BASIS; EFFICACY TRIAL; DOUBLE-BLIND; T-CELLS; INFECTION; RESPONSES; BROAD; PROTECTION;

D O I：

10.1038/ni.2264

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A vaccine against human immunodeficiency virus (HIV) seems to be on the horizon. Correlates of risk of infection for the RV144 trial have been found. There is understanding of what makes HIV envelope-specific antibodies broadly neutralizing and new T cell vaccine approaches can overcome virus variability.

引用

页码：423 / 427

页数：5

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