Non-viral environmental risk factors for nasopharyngeal carcinoma: A systematic review

被引：146

作者：

Jia, Wei-Hua ^{[1
]}

Qin, Hai-De ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, Dept Expt Res, State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R China

来源：

SEMINARS IN CANCER BIOLOGY | 2012年 / 22卷 / 02期

关键词：

Nasopharyngeal carcinoma; Epidemiology; Non-viral environmental risk factors; Interaction; Pathogenesis; EPSTEIN-BARR-VIRUS; FAMILY-BASED ASSOCIATION; GENOME-WIDE ASSOCIATION; CIGARETTE-SMOKING; SALTED FISH; FORMALDEHYDE EXPOSURE; OCCUPATIONAL-EXPOSURE; PRESERVED FOODS; GENETIC POLYMORPHISMS; SUSCEPTIBILITY LOCUS;

D O I：

10.1016/j.semcancer.2012.01.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review aims to systematically summarize the epidemiological studies on nasopharyngeal carcinoma (NPC) conducted over the past half century, covering descriptive epidemiological studies and reports on non-viral risk factors. Multiple lines of epidemiologic evidence for established risk factors are systematically presented in comprehensive tables. The potential interactions among environmental factors and genetic components, and also the impacts of parallel sequencing technology on the aetiology of NPC are discussed. Finally, we propose a modified model for the pathogenesis of nasopharyngeal carcinoma based on the current knowledge. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：117 / 126

页数：10

共 136 条

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