Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives

被引：47

作者：

Fiorito, Serena ^{[1
]}

Epifano, Francesco ^{[1
]}

Bruyere, Celine ^{[2
]}

Mathieu, Veronique ^{[2
]}

Kiss, Robert ^{[2
]}

Genovese, Salvatore ^{[1
]}

机构：

[1] Univ G dAnnunzio, Dipartimento Farm, I-66100 Chieti, CH, Italy

[2] Univ Libre Bruxelles, Fac Pharm, Lab Cancerol & Toxicol Expt, B-1050 Brussels, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 02期

关键词：

Lapachol; In vitro growth inhibition; Cancer; 1,4-Naphthoquinones; NAPHTHOQUINONE DERIVATIVES; SODIUM-PUMP; PRODUCTS;

D O I：

10.1016/j.bmcl.2013.12.049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 17 selected natural and semisynthetic 1,4-naphthoquinones were synthesized, and their growth inhibitory activity was evaluated in vitro. The compounds were tested on six human cancer cell lines using the MTT colorimetric assay. The data revealed that of the chemicals under study only lapachol, its acetate and 3-geranyllawsone displayed the highest activity, recording mean IC50 values ranging from 15 to 22 mu M. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：454 / 457

页数：4

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