Expression of MMP-9 and TIMP-1 in Lesions of Systemic Sclerosis and Its Implications

被引：10

作者：

Meng, Chi ^{[1
]}

Chen, Xu'e ^{[2
]}

Li, Jiawen ^{[1
]}

Wu, Yan ^{[1
]}

Liu, Houjun ^{[1
]}

机构：

[1] Huazhong Univ Sci Technol, Dept Dermatol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

[2] Guizhou Prov Peoples Hosp, Dept Dermatol, Guiyang 550002, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2008年 / 28卷 / 04期

关键词：

MMP-9; TIMP-1; systemic sclerosis;

D O I：

10.1007/s11596-008-0424-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to investigate the role of MMP-9 and TIMP-1 in the pathogenesis of systemic sclerosis, the expression of MMP-9 and TIMP-1 was immunohistochemically detected in skin lesions of the patients with diffuse cutaneous systemic sclerosis, skin lesions of the patients with limited cutaneous systemic sclerosis, and skin tissues of normal subjects. The results showed that the expression of MMP-9 in lesions of diffuse cutaneous systemic sclerosis was significantly lower than that of normal skins (P<0.05). However, no significant difference in the level of MMP-9 in the limited cutaneous systemic sclerosis and normal skin was found. Meanwhile, the expression of TIMP-1 in lesions of diffuse cutaneous systemic sclerosis and limited cutaneous systemic sclerosis were significantly higher than that of normal skins (both P<0.05). It was suggested that the expression of MMP-9 and TIMP-1 might play an important role in the development of systemic sclerosis.

引用

页码：480 / 482

页数：3

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