Effectiveness of Chinese herbal medicine for cancer palliative care: overview of systematic reviews with meta-analyses

被引：33
作者：
Chung, Vincent C. H. [1 ,2 ]
Wu, Xinyin [1 ,2 ]
Hui, Edwin P. [1 ,3 ]
Ziea, Eric T. C. [4 ]
Ng, Bacon F. L. [4 ]
Ho, Robin S. T. [2 ]
Tsoi, Kelvin K. F. [2 ,5 ]
Wong, Samuel Y. S. [1 ,2 ]
Wu, Justin C. Y. [1 ,6 ]
机构：
[1] Chinese Univ Hong Kong, Hong Kong Inst Integrat Med, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Comprehens Canc Trials Unit, Hong Kong, Hong Kong, Peoples R China
[4] Hong Kong Hosp Author, Chinese Med Dept, Hong Kong, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Big Data Decis Analyt Res Ctr, Hong Kong, Hong Kong, Peoples R China
[6] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
来源：
SCIENTIFIC REPORTS | 2015年 / 5卷
关键词：
RANDOMIZED CONTROLLED-TRIALS; METHODOLOGICAL QUALITY; MEASUREMENT TOOL; AMSTAR;
D O I：
10.1038/srep18111
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Chinese herbal medicines (CHM) are often used in managing cancer related symptoms but their effectiveness and safety is controversial. We conducted this overview of meta-analyses to summarize evidence on CHM for cancer palliative care. We included systematic reviews (SRs) with meta-analyses of CHM clinical trials on patients diagnosed with any type of cancer. Methodological quality of included meta-analyses was assessed with the Methodological Quality of Systematic Reviews (AMSTAR) Instrument. Fifty-one SRs with meta-analyses were included. They covered patients with lung (20 SRs), gastric (8 SRs), colorectal (6 SRs), liver (6 SRs), breast (2 SRs), cervical (1 SR), esophageal (1 SR), and nasopharyngeal (1 SR) cancers. Six SRs summarized evidence on various types of cancer. Methodological quality of included meta-analyses was not satisfactory. Overall, favorable therapeutic effects in improving quality of life among cancer patients have been reported. Conflicting evidence exists for the effectiveness of CHM in prolonging survival and in reducing chemotherapy and/or radiotherapy related toxicities. No serious adverse effects were reported in all included studies. Evidence indicated that CHM could be considered as an option for improving quality of life among patients receiving palliative care. It is unclear if CHM may increase survival, or reduce therapy related toxicities.
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页数：15
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