Kinetics of IgM and IgA Antibody Response to 23-Valent Pneumococcal Polysaccharide Vaccination in Healthy Subjects

被引:23
作者
Schuetz, Katharina [1 ]
Hughes, Richard G. [2 ]
Parker, Antony [2 ]
Quinti, Isabella [3 ]
Thon, Vojtech [4 ]
Cavaliere, Monica [3 ]
Wuerfel, Martina [5 ]
Herzog, Wilhelm [5 ]
Gessner, J. Engelbert [6 ]
Baumann, Ulrich [1 ]
机构
[1] Hannover Med Sch, Clin Immunodeficiencies Paediat Pulmonol Allergy, D-30625 Hannover, Germany
[2] Binding Site Grp Ltd, Birmingham, W Midlands, England
[3] Univ Roma La Sapienza, I-00185 Rome, Italy
[4] Masaryk Univ, Dept Clin Immunol & Allergy, Fac Med, St Annes Univ Hosp, Brno, Czech Republic
[5] Binding Site Deutschland GmbH, Schwetzingen, Germany
[6] Hannover Med Sch, D-30625 Hannover, Germany
关键词
Pneumococcal polysaccharides; vaccination; PCP-IgM; PCP-IgA; 23 PCP ELISA; PCP antibody kinetics; COMMON VARIABLE IMMUNODEFICIENCY; MEMORY B-CELLS; STREPTOCOCCUS-PNEUMONIAE; DEFICIENCY; DISEASE; ADULTS;
D O I
10.1007/s10875-012-9792-y
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Purpose A poor antibody response of IgM and IgA antibodies upon vaccination with pneumococcal polysaccharides (PnPS) is discussed as independent risk factors for bronchiectasis in patients with antibody deficiency syndrome (ADS) receiving immunoglobulin replacement therapy. However, the kinetics of the specific IgM and IgA response to vaccination with multivalent pneumococcal polysaccharides requires a more detailed knowledge. In this study we aimed i) to develop a standardised multivalent PnPS-IgM and IgA-ELISA, and ii) to compare the sensitivity of the multivalent to the serotype specific antibody response, and iii) to determine the kinetics of the anti-PnPS IgM and IgA antibodies in healthy subjects. Methods We immunised n=20 healthy adults with a 23-valent PnPS vaccine (Pneumovax (R)). The kinetics of the 23-valent antibody response was assessed for 1 year with newly developed ELISAs for IgM and IgA isotypes, along with serotype specific responses. Results The IgA and IgM antibody response peaked at 2 and 3 weeks, respectively. IgM antibody levels remained at a plateau (above 80 % of peak response) for 3 months. After one year, specific antibody levels were still at about 30 % of the peak response. The 23-valent antibody response yielded significantly higher responder rates than assessment of single serotypes. Conclusion Testing the IgM and IgA immune response to polysaccharide vaccination with a multivalent PnPS ELISA may be a feasible tool for assessment of the immune function in patient groups who receive IgG replacement therapy.
引用
收藏
页码:288 / 296
页数:9
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