Catalyst-free, efficient and one pot protocol for synthesis of nitriles from aldehydes using glycerol as green solvent

被引：22
|
作者：
Ingale, Ajit P. [1 ]
Patil, Shripad M. [2 ]
Shinde, Sandeep V. [1 ]
机构：
[1] Swami Ramanand Teerth Marathwada Univ, Dept Chem, Pratibha Niketan Coll, Nanded 431606, Maharashtra, India
[2] Savitribai Phule Pune Univ, Dept Chem, Dada Patil Coll, Ahmednagar 414402, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 52期
关键词：
Glycerol; Aldehydes; Nitriles; C-H CYANATION; AROMATIC NITRILES; HIGHLY EFFICIENT; CONVERSION; AMMONIA; N; N-DIMETHYLFORMAMIDE; CONVENIENT; INHIBITORS; ALDOXIMES; ARENES;
D O I：
10.1016/j.tetlet.2017.11.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We described herein the novel, efficient and one-pot catalyst free protocol for the synthesis of nitriles from aldehydes by using hydroxyl amine hydrochlorides in glycerol as a green solvent. This protocol was efficiently used for transformation of aromatic aldehydes bearing electron-withdrawing and electron -donating groups into a aryl nitriles in good to excellent yields. The methodology offers a very simple, efficient and environmentally benign procedure. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4845 / 4848
页数：4
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