State-dependency in brain stimulation studies of perception and cognition

被引：431

作者：

Silvanto, Juha ^{[1
,2
]}

Muggleton, Neil

Walsh, Vincent ^{[3
,4
]}

机构：

[1] Univ Essex, Dept Psychol, Colchester CO4 3SQ, Essex, England

[2] Boston Univ, Sch Med, Dept Anat & Neurobiol, Lab Cerebral Dynam Plast & Rehabil, Boston, MA 02118 USA

[3] UCL, Inst Cognit Neurosci, London WC1N 3AR, England

[4] UCL, Dept Psychol, London WC1N 3AR, England

来源：

TRENDS IN COGNITIVE SCIENCES | 2008年 / 12卷 / 12期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tics.2008.09.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We address the importance of understanding initial states of neuronal populations and of state-dependent responses in cognitive neuroscience experiments with special emphasis on brain stimulation studies of perception and cognition. The approach we present is based on evidence that behavioural and perceptual effects of transcranial magnetic stimulation (TMS) are determined by initial neural activation state; by systematically manipulating neural activation states before application of TMS, one can selectively target specific, even spatially overlapping neural populations within the affected region. This approach is potentially of great benefit to cognitive neuroscience and remediation programmes as it combines high spatial and functional resolution with the ability to assess causality.

引用

页码：447 / 454

页数：8