Polyglutamic acid as raw material for drug carriers

被引：1
作者：
Guo, H. [1 ]
Fan, L. [1 ]
Ding, L. [1 ]
Hou, H. L. [1 ]
Yang, W. Q. [1 ]
Fan, S. J. [2 ]
机构：
[1] Qiqihar Med Univ, Dept Sci Res, Qiqihar 161006, Peoples R China
[2] Qiqihar Med Univ, Res Inst Med & Pharm, Qiqihar 161006, Peoples R China
来源：
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES | 2022年 / 17卷 / 04期
关键词：
Polyglutamic acid; Nanoparticles; Response surface methodology; HCPT; GAMMA-GLUTAMIC ACID; DELIVERY SYSTEM; IN-VITRO; NANOPARTICLES; CAMPTOTHECIN; BIOPOLYMER; EFFICACY; RELEASE; VIVO; PH;
D O I：
10.15251/DJNB.2022.174.1399
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
gamma-PGA-PAE nanomaterials were prepared by spontaneous assembly of gamma-PGA through condensation reaction, and preparation process of nanomaterials was optimized. HCPT/PGA-PAE nanospheres were prepared by using 10-hydroxycamptothecin as embedding drug, and the nanospheres prepared under the optimal conditions were characterized. The results showed that gamma-PGA-PAE nanomaterials were successfully prepared with spherical shape and uniform distribution. HCPT/PGA-PAE nanospheres had high encapsulation rate and drug loading. The optimization of the processing conditions of nanomaterials by response surface method (RSM) is a feasible method to improve the utilization rate of gamma-PGA, which provides a theoretical basis for the synthesis of nanomaterials in the future.
引用
收藏
页码：1399 / 1415
页数：17
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