Association between OPCRIT dimensions and polymorphisms of HPA axis genes in bipolar disorder

被引：13
|
作者：
Leszczynska-Rodziewicz, Anna [2 ]
Maciukiewicz, Malgorzata [2 ]
Szczepankiewicz, Aleksandra [2 ,3 ]
Poglodzinski, Andrzej [1 ]
Hauser, Joanna [2 ]
机构：
[1] Poznan Univ Med Sci, Dept Adult Psychiat, PL-60572 Poznan, Poland
[2] Poznan Univ Med Sci, Psychiat Genet Unit, PL-60572 Poznan, Poland
[3] Poznan Univ Med Sci, Lab Mol & Cell Biol, Dept Pulmonol Pediat Allergy & Clin Immunol, PL-60572 Poznan, Poland
来源：
JOURNAL OF AFFECTIVE DISORDERS | 2013年 / 151卷 / 02期
关键词：
HPA axis; Genes; OPCRIT dimension; Bipolar disorder; CONFIRMATORY FACTOR-ANALYSIS; SYMPTOM DIMENSIONS; MAJOR DEPRESSION; ANTIDEPRESSANT TREATMENT; PSYCHOTIC ILLNESS; VASOPRESSIN V1B; PANIC DISORDER; CRHR1; GENE; POPULATION; AVPR1B;
D O I：
10.1016/j.jad.2013.08.012
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The aim of the study was to investigate the possible association between polymorphisms of HPA axis genes-CRHR1 (corticotrophin-releasing hormone receptor), NR3C1 (glucocorticoid receptor) and AVPR1B (arginine vasopressin receptor) and dimensions of bipolar disorder assessed by OPCRIT. We examined 560 patients with diagnosis of bipolar disorder (n=457) and unipolar disorder (n=103). Diagnosis was established by SCID and POUT. We found association between polymorphisms of AVPR1b gene and psychotic dimension and CRHR1 polymorphisms and excitement and psychotic dimension. Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：744 / 747
页数：4
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