Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis

被引：13
作者：
Ito, Yoshinori [1 ]
Kawamura, Yoshiki [2 ]
Iwata, Seiko [3 ]
Kawada, Jun-ichi
Yoshikawa, Tetsushi [2 ]
Kimura, Hiroshi [3 ]
机构：
[1] Nagoya Univ, Dept Pediat, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan
[2] Fujita Hlth Univ, Sch Med, Dept Pediat, Toyoake, Aichi 47011, Japan
[3] Nagoya Univ, Dept Virol, Grad Sch Med, Nagoya, Aichi 4668550, Japan
来源：
PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 02期
基金：
日本学术振兴会;
关键词：
Epstein-Barr virus; hemophagocytic lymphohistiocytosis; T lymphocyte; ACTIVE EBV INFECTION; CD5; DOWN-REGULATION; QUANTITATIVE-ANALYSIS; CELLS; EXPANSION;
D O I：
10.1002/pbc.24319
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
EpsteinBarr virus (EBV) is the most common infectious cause of non-genetic hemophagocytic lymphohistiocytosis (HLH). To investigate EBV-infected lymphocytes and immune dysfunction in EBV-associated HLH, blood samples from a 6-year-old boy were longitudinally analyzed using molecular techniques. EBV-positive lymphocytes were detected as CD5+, CD8+, and/or HLA DR+ lymphocytes on Day 25 of the disease, mostly disappearing thereafter. CD8+ cells specific for lytic antigen BRLF1 were detected, but cells specific for latent antigens EBNA3 and LMP2 were not. EBV genes EBNA1, LMP1, LMP2, EBER1, BARTs were detected, suggesting a latency type II gene expression pattern in this case. Pediatr Blood Cancer 2013;60:326328. (c) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：326 / 328
页数：3
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