Tricycles by a New Ugi Variation and Pictet-Spengler Reaction in One Pot

被引：27

作者：

Sinha, Mantosh K. ^{[2
]}

Khoury, Kareem ^{[2
]}

Herdtweck, Eberhardt ^{[3
]}

Doemling, Alexander ^{[1
,2
]}

机构：

[1] Univ Groningen, Dept Drug Design, NL-9700 AD Groningen, Netherlands

[2] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA USA

[3] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 25期

关键词：

multicomponent reactions; natural products; Pictet-Spengler reaction; Ugi reaction; MULTICOMPONENT REACTIONS; DIVERSE SYNTHESIS; DERIVATIVES; EFFICIENT; PRAZIQUANTEL; HETEROCYCLES; DISCOVERY; LIBRARIES; CHEMISTRY; SYSTEM;

D O I：

10.1002/chem.201300962

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Subsequent mild cyclization of aromatic substrates by Pictet-Spengler condensation stereoselectively gave new tricyclic compounds. Examples are described in decent yields over two steps in one pot, and a crystal structure is also presented to support the proposed structures (see figure). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8048 / 8052

页数：5

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