Tricycles by a New Ugi Variation and Pictet-Spengler Reaction in One Pot

被引:27
作者
Sinha, Mantosh K. [2 ]
Khoury, Kareem [2 ]
Herdtweck, Eberhardt [3 ]
Doemling, Alexander [1 ,2 ]
机构
[1] Univ Groningen, Dept Drug Design, NL-9700 AD Groningen, Netherlands
[2] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA USA
[3] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany
关键词
multicomponent reactions; natural products; Pictet-Spengler reaction; Ugi reaction; MULTICOMPONENT REACTIONS; DIVERSE SYNTHESIS; DERIVATIVES; EFFICIENT; PRAZIQUANTEL; HETEROCYCLES; DISCOVERY; LIBRARIES; CHEMISTRY; SYSTEM;
D O I
10.1002/chem.201300962
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Subsequent mild cyclization of aromatic substrates by Pictet-Spengler condensation stereoselectively gave new tricyclic compounds. Examples are described in decent yields over two steps in one pot, and a crystal structure is also presented to support the proposed structures (see figure). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:8048 / 8052
页数:5
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