Tuberculosis during TNF-α inhibitor therapy, despite screening

被引：10

作者：

Hofland, Regina W. ^{[1
]}

Thijsen, Steven F. T. ^{[2
]}

Verhagen, Marc A. M. T. ^{[3
]}

Schenk, Yolande ^{[4
]}

Bossink, Ailko W. J. ^{[1
]}

机构：

[1] Diakonessenhuis Utrecht, Dept Pulmonol & TB, NL-3582 KE Utrecht, Netherlands

[2] Diakonessenhuis Utrecht, Dept Med Microbiol & Immunol, NL-3582 KE Utrecht, Netherlands

[3] Diakonessenhuis Utrecht, Dept Gastroenterol, NL-3582 KE Utrecht, Netherlands

[4] Diakonessenhuis Utrecht, Dept Rheumatol, NL-3582 KE Utrecht, Netherlands

来源：

THORAX | 2013年 / 68卷 / 11期

关键词：

Tuberculosis; Immunodeficiency; Respiratory Infection; Infection Control;

D O I：

10.1136/thoraxjnl-2012-202974

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

As part of a prospective study on the safety of TNF- inhibitor therapy after screening for and treatment of latent tuberculosis infection (LTBI), we report two patients who developed active tuberculosis (TB) infection during TNF- inhibitor therapy, despite negative screening for LTBI. The clinical history is suggestive of a primary infection acquired during travelling to TB-endemic countries. In this lesson of the month we would like to highlight the risk of travelling to TB-endemic areas in patients treated with TNF- inhibitor therapy.Screening for latent tuberculosis infection is not enough to prevent tuberculosis in patients treated with TNF- inhibitor therapy Screening for latent tuberculosis infection is not enough to prevent tuberculosis in patients treated with TNF-alpha inhibitor therapy

引用

页码：1079 / 1080

页数：2

共 5 条

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