Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis

被引：8

作者：

Morita, Susumu ^{[1
]}

Joshita, Satoru ^{[1
]}

Umemura, Takeji ^{[1
]}

Katsuyama, Yoshihiko ^{[2
]}

Kimura, Takefumi ^{[1
]}

Komatsu, Michiharu ^{[1
]}

Matsumoto, Akihiro ^{[1
]}

Yoshizawa, Kaname ^{[1
]}

Kamijo, Astushi ^{[4
]}

Yamamura, Nobuyoshi ^{[4
]}

Tanaka, Eiji ^{[1
]}

Ota, Masao ^{[3
]}

机构：

[1] Shinshu Univ, Dept Med, Sch Med, Div Gastroenterol & Hepatol, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Dept Legal Med, Sch Med, Matsumoto, Nagano 3908621, Japan

[3] Shinshu Univ Hosp, Dept Pharm, Matsumoto, Nagano, Japan

[4] Suwa Red Cross Hosp, Dept Gastroenterol, Suwa, Japan

来源：

HUMAN IMMUNOLOGY | 2013年 / 74卷 / 02期

关键词：

TOLL-LIKE-RECEPTOR-4 GENE POLYMORPHISMS; INFLAMMATORY-BOWEL-DISEASE; AUTOIMMUNE PANCREATITIS; ULCERATIVE-COLITIS; SUSCEPTIBILITY; LIVER; LIPOPOLYSACCHARIDE; HAPLOTYPES; SEVERITY; VARIANT;

D O I：

10.1016/j.humimm.2012.10.022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary biliary cirrhosis (PBC) is characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often result in liver failure. Toll-like receptor (TLR) 4 recognizes lipopolysaccharides of Gram-negative bacteria. Infectious agents have been suspected to play a crucial role in PBC pathogenesis since TLR4 expression was found in bile duct epithelial cells and periportal hepatocytes in liver tissues of PBC. To assess the potential contribution of TLR4 SNPs to the development of this disease, we genotyped five SNPs in TLR4 in 261 PBC patients and 359 controls using a TaqMan assay. No significant positive associations with either PBC susceptibility or progression were uncovered. These results indicate that TLR4 polymorphisms do not play a prominent role in the development of PBC in Japanese patients. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：219 / 222

页数：4

共 33 条

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