Circular Polarized Light Activated Chiral Satellite Nanoprobes for the Imaging and Analysis of Multiple Metal Ions in Living Cells

被引：97

作者：

Gao, Rui ^{[1
]}

Xu, Liguang ^{[1
]}

Hao, Changlong ^{[1
]}

Xu, Chuanlai ^{[1
]}

Kuang, Hua ^{[1
]}

机构：

[1] Jiangnan Univ, Key Lab Synthet & Biol Colloids, Minist Educ,Sch Food Sci & Technol, Int Joint Res Lab Biointerface & Biodetect,State, Wuxi 214122, Jiangsu, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 12期

基金：

中国国家自然科学基金;

关键词：

analysis; bioimaging; circular polarized light; living cells; metal ions; GOLD; DNAZYME; QUANTIFICATION; SENSOR; PH;

D O I：

10.1002/anie.201814282

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we constnict a handedness-dependent circular polarized light (CPL)-activated chiral satellite assemblies formed from DNAzymes and spiny platinum modified with gold nanorods and upconversion nanoparticles (UCNPs), enabling the simultaneous quantitative analysis of multiple divalent metal ions in living cells. The chiral nanoprobes, in coordination with their corresponding divalent metal ions under 980 nm left circular polarized (LCP) light illumination, served as an in situ confocal bioimaging platform for the quantitation of the given intracellular metal ions. The limit of detection (LOD) of the chiral probes in living cells is 1.1 nmol/ 10(6 )cells, 1.02 nmol/10(6) cells and 0.45 nmol/10(6) cells for Zn+, Mg2+, and Cu2+, respectively.

引用

页码：3913 / 3917

页数：5

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