Gamma interferon primes productive human immunodeficiency virus infection in astrocytes

被引:50
作者
Carroll-Anzinger, D [1 ]
Al-Harthi, L [1 ]
机构
[1] Rush Univ, Med Ctr, Dept Immunol Microbiol, Chicago, IL 60612 USA
关键词
D O I
10.1128/JVI.80.1.541-544.2006
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Considerable controversy exists over whether astrocytes can support human immunodeficiency virus (HIV) infection. We evaluated the impact of three cytokines critical to the development of HIV neuropathogenesis, gamma interferon (IFN-gamma), granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha, on priming astrocytes for HIV infection. We demonstrate that IFN-gamma was the most potent in its ability to facilitate substantial productive HIV infection of an astroglioma cell line (U87MG) and human fetal astrocytes (HFA). The mechanism of IFN-gamma-mediated priming of HIV in HFA is unlikely to be at the level of up-regulation of receptors and coreceptors relevant to HIV entry. These data demonstrate that cytokine priming can alter HIV replication in astrocytes.
引用
收藏
页码:541 / 544
页数:4
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