MDM2 and mitochondrial function: One complex intersection

被引：17

作者：

Rubio-Patino, Camila ^{[1
,2
]}

Trotta, Andrew Paul ^{[1
,2
]}

Chipuk, Jerry Edward ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Oncol Sci, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Tisch Canc Inst, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Dermatol, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Dept Dermatol, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[6] Icahn Sch Med Mt Sinai, Diabet Obes & Metab Inst, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2019年 / 162卷

关键词：

Apoptosis; Bioenergetics; Complex I; Electron transport chain; MDM2; Mitochondria; Oncogene; p53; Tumor suppressor; DEPENDENT PROTEIN-KINASE; DNA-ENCODED SUBUNITS; P53; PROTEIN; OXIDATIVE-PHOSPHORYLATION; EMBRYONIC LETHALITY; MDM2-DEFICIENT MICE; ELECTRON-TRANSPORT; GENE AMPLIFICATION; OVEREXPRESSION; CANCER;

D O I：

10.1016/j.bcp.2018.10.032

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regulation of NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1) and MT-ND6 (NADH dehydrogenase 6), MDM2 decreases the function and efficiency of Complex I (CI). These observations propose several important questions: (1) Where does MDM2 affect CI activity? (2) What are the cellular consequences of MDM2-mediated regulation of CI? (3) What are the physiological implications of these interactions? Here, we will address these questions and position these observations within the MDM2 literature.

引用

页码：14 / 20

页数：7

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