MDM2 and mitochondrial function: One complex intersection

被引：13

作者：

Rubio-Patino, Camila ^{[1
,2
]}

Trotta, Andrew Paul ^{[1
,2
]}

Chipuk, Jerry Edward ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Oncol Sci, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Tisch Canc Inst, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Dermatol, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Dept Dermatol, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

[6] Icahn Sch Med Mt Sinai, Diabet Obes & Metab Inst, One Gustave L Levy Pl,Box 1130, New York, NY 10029 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2019年 / 162卷

关键词：

Apoptosis; Bioenergetics; Complex I; Electron transport chain; MDM2; Mitochondria; Oncogene; p53; Tumor suppressor; DEPENDENT PROTEIN-KINASE; DNA-ENCODED SUBUNITS; P53; PROTEIN; OXIDATIVE-PHOSPHORYLATION; EMBRYONIC LETHALITY; MDM2-DEFICIENT MICE; ELECTRON-TRANSPORT; GENE AMPLIFICATION; OVEREXPRESSION; CANCER;

D O I：

10.1016/j.bcp.2018.10.032

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regulation of NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1) and MT-ND6 (NADH dehydrogenase 6), MDM2 decreases the function and efficiency of Complex I (CI). These observations propose several important questions: (1) Where does MDM2 affect CI activity? (2) What are the cellular consequences of MDM2-mediated regulation of CI? (3) What are the physiological implications of these interactions? Here, we will address these questions and position these observations within the MDM2 literature.

引用

页码：14 / 20

页数：7

共 50 条

[1] MDM2 function
Lozano, G.
Montes de Oca Luna, R.
B B A - Biomembranes, 1377 (02):
[2] MDM2 function
Lozano, G
Luna, RMD
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1998, 1377 (02): : M55 - M59
[3] Analysis of the degradation function of Mdm2
Kubbutat, MHG
Ludwig, RL
Levine, AJ
Vousden, KH
CELL GROWTH & DIFFERENTIATION, 1999, 10 (02): : 87 - 92
[4] Complex I and MDM2: hit me baby one more time
Chipuk, Jerry Edward
MOLECULAR & CELLULAR ONCOLOGY, 2019, 6 (04):
[5] Dissecting MDM2 function in medulloblastoma pathogenesis
Mendrysa, Susan M.
Malek, Reem
MOLECULAR CANCER RESEARCH, 2014, 12
[6] Mdm2 E3 ubiquitin ligase function is dispensable for the degradation of Mdm2 itself
Kim, Tae-Hyung
Zhang, Yanping
CANCER RESEARCH, 2013, 73
[7] Mdm2 function in the UV response.
Saucedo, L
Holubar, M
Perry, ME
MOLECULAR BIOLOGY OF THE CELL, 1998, 9 : 489A - 489A
[8] Function and dysfunction of the human oncoprotein MDM2
Deb, SP
FRONTIERS IN BIOSCIENCE, 2002, 7 : D235 - D243
[9] Structure and function of MDM2 and MDM4 in health and disease
Zhu, Ivy Yiyi
Lloyd, Alec
Critchley, William R.
Saikia, Queen
Jade, Dhananjay
Divan, Aysha
Zeqiraj, Elton
Harrison, Michael A.
Brown, Christopher J.
Ponnambalam, Sreenivasan
BIOCHEMICAL JOURNAL, 2025, 482 (04) : 241 - 262
[10] Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53
Arena, Giuseppe
Cisse, Madi Yann
Pyrdziak, Samuel
Chatre, Laurent
Riscal, Romain
Fuentes, Maryse
Arnold, Jamie Jon
Kastner, Markus
Gayte, Laurie
Bertrand-Gaday, Christelle
Nay, Kevin
Angebault-Prouteau, Claire
Murray, Kerren
Chabi, Beatrice
Koechlin-Ramonatxo, Christelle
Orsetti, Beatrice
Vincent, Charles
Casas, Francois
Marine, Jean-Christophe
Etienne-Manneville, Sandrine
Bernex, Florence
Lombes, Anne
Cameron, Craig Eugene
Dubouchaud, Herve
Ricchetti, Miria
Linares, Laetitia Karine
Le Cam, Laurent
MOLECULAR CELL, 2018, 69 (04) : 594 - +

← 1 2 3 4 5 →