Increased apolipoprotein B serum concentration in Alzheimer's disease

被引：68
作者：
Caramelli, P
Nitrini, R
Maranhao, R
Lourenço, ACG
Damasceno, MC
Vinagre, C
Caramelli, B
机构：
[1] Univ Sao Paulo, Sch Med, Dept Neurol, BR-01332000 Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Dept Emergency Med, BR-01332000 Sao Paulo, Brazil
[3] Univ Sao Paulo, Sch Med, Dept Cardiol, Inst Heart, BR-01332000 Sao Paulo, Brazil
[4] Univ Sao Paulo, Fac Pharmaceut Sci, BR-01332000 Sao Paulo, Brazil
来源：
ACTA NEUROLOGICA SCANDINAVICA | 1999年 / 100卷 / 01期
关键词：
Alzheimer's disease; dementia; atherosclerosis; apolipoprotein; cholesterol;
D O I：
10.1111/j.1600-0404.1999.tb00724.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective - To investigate the lipoprotein profile in a group of Alzheimer's disease (AD) patients. Patients and methods - Twenty-four patients with AD and 32 elderly controls were evaluated. Fasting blood samples were obtained for determination of total VLDL, HDL and LDL cholesterol, lipoprotein (a), triglycerides, apolipoprotein Al and apolipoprotein B. Results - Significantly higher levels of apolipoprotein B were found in AD patients (P=0.004), whereas the concentration of lipoprotein (a) and plasma lipids was not statistically different. Apo B levels were similar between AD patients with or without leukoaraiosis on CT scan. Conclusion - AD patients had high serum concentration of apolipoprotein B. This finding suggests that apolipoprotein E may not be the single factor in lipid metabolism to play a role in AD pathogenesis.
引用
收藏
页码：61 / 63
页数：3
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