Epigenetic changes brought about by perinatal stressors: A brief review of the literature

被引：6

作者：

Billack, Blase ^{[1
]}

Serio, Ryan ^{[2
]}

Silva, Ilton ^{[3
]}

Kinsley, Craig H. ^{[3
]}

机构：

[1] St Johns Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, Jamaica, NY 11439 USA

[2] St Johns Univ, Inst Biotechnol, Jamaica, NY 11439 USA

[3] Univ Richmond, Dept Psychol, Ctr Neurosci, Richmond, VA 23173 USA

来源：

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 2012年 / 66卷 / 03期

关键词：

Gonadal hormones; Epigenetics; Heterosexuality; Homosexuality; Postnatal stress; Prenatal stress; Perinatal stress; Sexual differentiation; Social behaviors; Stress; DNA methylation; Hormones; MEDIAL PREOPTIC AREA; METABOTROPIC GLUTAMATE RECEPTORS; CORTICOTROPIN-RELEASING HORMONE; HYPOTHALAMIC VENTROMEDIAL NUCLEUS; INDUCED PROLACTIN-RELEASE; MESSENGER-RNA EXPRESSION; PITUITARY-ADRENAL AXIS; PRENATAL STRESS; SEX-DIFFERENCES; MALE-RATS;

D O I：

10.1016/j.vascn.2012.08.169

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Numerous studies employing various animal models have found that perinatal stress, encountered in utero during sensitive developmental stages or shortly after birth, disrupts both sexual differentiation and sexual behavior in offspring. The biochemical, cellular, genetic and epigenetic events which are involved in the organismal response to perinatal stress are currently under investigation. Methods, Results and Discussion: In this review, the reader is introduced to perinatal stressors as a toxicological phenomenon, and several recently characterized epigenetic responses to said stressors are discussed. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：221 / 231

页数：11

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